Reactome | PKMTs methylate histone lysines

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PKMTs methylate histone lysines Show undefined attributes

created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10912716
displayName	PKMTs methylate histone lysines
eventOf	[Pathway:R-DME-3247509] Chromatin modifying enzymes - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DME-5159250] ATF7IP binds SETDB1 - Drosophila melanogaster [Reaction:R-DME-5423038] SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) - Drosophila melanogaster [Reaction:R-DME-5651654] SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) - Drosophila melanogaster [Reaction:R-DME-5651657] SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) - Drosophila melanogaster
inferredFrom	[Pathway:R-HSA-3214841] PKMTs methylate histone lysines - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	PKMTs methylate histone lysines
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:56210] Drosophila melanogaster
stId	R-DME-3214841
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-3247509] Chromatin modifying enzymes
(inferredTo)	[Pathway:R-HSA-3214841] PKMTs methylate histone lysines

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