Reactome | PKMTs methylate histone lysines

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PKMTs methylate histone lysines Show undefined attributes

created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10101087
displayName	PKMTs methylate histone lysines
eventOf	[Pathway:R-MMU-3247509] Chromatin modifying enzymes - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-MMU-5159245] SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) - Mus musculus [Reaction:R-MMU-5637686] WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) - Mus musculus [Reaction:R-MMU-5244692] Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) - Mus musculus [Reaction:R-MMU-5634750] EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9) - Mus musculus [Reaction:R-MMU-5634729] EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9) - Mus musculus [Reaction:R-MMU-5634802] MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) - Mus musculus [Reaction:R-MMU-4827382] SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) - Mus musculus [Reaction:R-MMU-5638332] PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27) - Mus musculus [Reaction:R-MMU-5638333] WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) - Mus musculus [Reaction:R-MMU-5649800] WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27) - Mus musculus [Reaction:R-MMU-5649802] WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) - Mus musculus [Reaction:R-MMU-4827383] WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) - Mus musculus [Reaction:R-MMU-5638157] WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L methylate methyl-lysine-37 of histone H3 (H3K36) - Mus musculus [Reaction:R-MMU-5638141] SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36) - Mus musculus [Reaction:R-MMU-5159250] ATF7IP binds SETDB1 - Mus musculus [Reaction:R-MMU-5649801] DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79) - Mus musculus [Reaction:R-MMU-5649764] DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79) - Mus musculus [Reaction:R-MMU-5649799] DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) - Mus musculus [Reaction:R-MMU-5423038] SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) - Mus musculus [Reaction:R-MMU-5651654] SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) - Mus musculus [Reaction:R-MMU-5651657] SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) - Mus musculus [Reaction:R-MMU-8865237] SETD6 methylates RELA in the NFkB complex - Mus musculus
inferredFrom	[Pathway:R-HSA-3214841] PKMTs methylate histone lysines - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	PKMTs methylate histone lysines
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-3214841
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-3247509] Chromatin modifying enzymes
(inferredTo)	[Pathway:R-HSA-3214841] PKMTs methylate histone lysines

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