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Schema
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Reaction
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Entries
SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20)
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authored
[InstanceEdit:5638142] Jupe, Steve, 2014-11-13
catalystActivity
[CatalystActivity:5651641] histone H4 methyltransferase activity of SUV420H1,SUV420H2,(SMYD3) [nucleoplasm]
category
transition
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:5651644] Jupe, Steve, 2014-11-24
dbId
5651654
displayName
SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20)
edited
[InstanceEdit:5674564] Jupe, Steve, 2015-02-13
eventOf
[Pathway:R-HSA-3214841] PKMTs methylate histone lysines - Homo sapiens
input
[SimpleEntity:R-ALL-77087] AdoMet [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-5423110] MeK21-HIST1H4 [nucleoplasm]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:5651651] A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin
maxDepth
1
modified
[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
name
SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20)
SUV420H1, SUV420H2, (SMYD3) methylate methyl-lysine-21 of histone H4 (H4K20)
SUV420H1, SUV420H2, (SMYD3) methylate Me2K21-histone H4 (H4K20)
SUV420H1, SUV420H2, (SMYD3) methylate Me2K21-histone H4
orthologousEvent
[Reaction:R-SPO-5651654] SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) - Schizosaccharomyces pombe
[Reaction:R-DME-5651654] SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) - Drosophila melanogaster
[Reaction:R-GGA-5651654] SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) - Gallus gallus
[Reaction:R-XTR-5651654] SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) - Xenopus tropicalis
[Reaction:R-DRE-5651654] SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) - Danio rerio
[Reaction:R-SSC-5651654] SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) - Sus scrofa
[Reaction:R-BTA-5651654] SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) - Bos taurus
[Reaction:R-CFA-5651654] SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) - Canis familiaris
[Reaction:R-RNO-5651654] SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) - Rattus norvegicus
[Reaction:R-MMU-5651654] SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) - Mus musculus
output
[SimpleEntity:R-ALL-77502] AdoHcy [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-5651652] Me2K21-HIST1H4 [nucleoplasm]
releaseDate
2015-03-15
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5643671] Motamedi, Mo, 2014-11-17
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-5651654
summation
[Summation:5651642] The di- and tri-methylation of lysine-21 of histone H4 (H4K2...
systematicName
SUV420H1,SUV420H2 transfer CH3 from AdoMet to MeK21-HIST1H4
Referrals
(hasEvent)
[Pathway:R-HSA-3214841] PKMTs methylate histone lysines
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