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Schema
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Reaction
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Entries
WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27)
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authored
[InstanceEdit:5638142] Jupe, Steve, 2014-11-13
catalystActivity
[CatalystActivity:5159247] histone H3 methyltransferase activity of WHSC1, WHSC1L1 [nucleoplasm]
category
transition
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:5638320] Jupe, Steve, 2014-11-13
dbId
5638333
displayName
WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27)
edited
[InstanceEdit:5674564] Jupe, Steve, 2015-02-13
eventOf
[Pathway:R-HSA-3214841] PKMTs methylate histone lysines - Homo sapiens
input
[SimpleEntity:R-ALL-77087] AdoMet [nucleoplasm]
[CandidateSet:R-HSA-4657030] Histone H3 [nucleoplasm]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:5638330] Multiple-myeloma-related WHSC1/MMSET isoform RE-IIBP is a histone methyltransferase with transcriptional repression activity
maxDepth
1
modified
[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
name
WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27)
WHSC1 methylates lysine-28 of histone H3
orthologousEvent
[Reaction:R-DRE-5638333] WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) - Danio rerio
[Reaction:R-SSC-5638333] WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) - Sus scrofa
[Reaction:R-BTA-5638333] WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) - Bos taurus
[Reaction:R-CFA-5638333] WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) - Canis familiaris
[Reaction:R-RNO-5638333] WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) - Rattus norvegicus
[Reaction:R-MMU-5638333] WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) - Mus musculus
output
[SimpleEntity:R-ALL-77502] AdoHcy [nucleoplasm]
[CandidateSet:R-HSA-5638329] MeK28-histone H3 [nucleoplasm]
releaseDate
2015-03-15
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5643671] Motamedi, Mo, 2014-11-17
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-5638333
summation
[Summation:5638322] WHSC1 (KMT3G, MMSET) is able to mono-, di- and trimethylate ...
systematicName
WHSC1 transfers CH3 from AdoMet to Replicative histone H3
Referrals
(hasEvent)
[Pathway:R-HSA-3214841] PKMTs methylate histone lysines
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