Reactome | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol

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Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Show undefined attributes

authored	[InstanceEdit:191331] Jassal, Bijay, 2007-01-19
created	[InstanceEdit:193476] D'Eustachio, P, 2007-02-19 17:36:33
dbId	193368
displayName	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
edited	[InstanceEdit:193470] D'Eustachio, P, 2007-02-12 16:13:17
eventOf	[Pathway:R-HSA-192105] Synthesis of bile acids and bile salts - Homo sapiens
figure	[Figure:193412] /figures/7alpha_pathway.jpg
goBiologicalProcess	[GO_BiologicalProcess:20533] bile acid biosynthetic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-192051] CYP7A1 7-hydroxylates CHOL - Homo sapiens [Reaction:R-HSA-192097] 7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one - Homo sapiens [Reaction:R-HSA-192157] CYP8B1 12-hydroxylates 4CHOL7aOLONE - Homo sapiens [Reaction:R-HSA-192067] 4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one - Homo sapiens [Reaction:R-HSA-192033] 4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one - Homo sapiens [Reaction:R-HSA-192036] 5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol - Homo sapiens [Reaction:R-HSA-192160] 5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol - Homo sapiens [Reaction:R-HSA-192010] 5beta-cholestan-3alpha, 7alpha, 12alpha-triol is translocated from the cytosol to the mitochondrial matrix - Homo sapiens [Reaction:R-HSA-193537] 5beta-cholestan-3alpha, 7alpha-diol is translocated from the cytosol to the mitochondrial matrix - Homo sapiens [Reaction:R-HSA-191999] CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol - Homo sapiens [Reaction:R-HSA-193393] 5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol - Homo sapiens [Reaction:R-HSA-192042] 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al - Homo sapiens [Reaction:R-HSA-193497] 5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al - Homo sapiens [Reaction:R-HSA-192054] 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA) - Homo sapiens [Reaction:R-HSA-193460] 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) - Homo sapiens [BlackBoxEvent:R-HSA-191971] THCA is translocated from the mitochondrial matrix to the cytosol - Homo sapiens [BlackBoxEvent:R-HSA-193519] DHCA is translocated from the mitochondrial matrix to the cytosol - Homo sapiens [Reaction:R-HSA-193401] THCA is conjugated with Coenzyme A (SLC27A2 VLCS) - Homo sapiens [Reaction:R-HSA-193424] DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) - Homo sapiens [Reaction:R-HSA-192137] THCA is conjugated with Coenzyme A (SLC27A5 BACS) - Homo sapiens [Reaction:R-HSA-193407] DHCA is conjugated with Coenzyme A (SLC27A5 BACS) - Homo sapiens [BlackBoxEvent:R-HSA-192325] 25(R) THCA-CoA is translocated from the cytosol to the peroxisome - Homo sapiens [BlackBoxEvent:R-HSA-193482] 25(R) DHCA-CoA is translocated from the cytosol to the peroxisome - Homo sapiens [Reaction:R-HSA-192056] Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA - Homo sapiens [Reaction:R-HSA-193452] Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA - Homo sapiens [Reaction:R-HSA-192335] 25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) - Homo sapiens [Reaction:R-HSA-193369] 25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA - Homo sapiens [Reaction:R-HSA-192331] 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA - Homo sapiens [Reaction:R-HSA-193535] 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA - Homo sapiens [Reaction:R-HSA-193455] (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA - Homo sapiens [Reaction:R-HSA-193508] (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA - Homo sapiens [Reaction:R-HSA-192341] Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA - Homo sapiens [Reaction:R-HSA-193533] Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA - Homo sapiens [Reaction:R-HSA-193385] Hydrolysis of choloyl-CoA to cholate and CoASH - Homo sapiens [BlackBoxEvent:R-HSA-193399] Cholate is translocated from the peroxisomal matrix to the cytosol - Homo sapiens [Reaction:R-HSA-192312] Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate - Homo sapiens [Reaction:R-HSA-193491] Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate - Homo sapiens [BlackBoxEvent:R-HSA-192315] Bile salts are translocated from the peroxisomal matrix to the cytosol - Homo sapiens [Reaction:R-HSA-193362] ABCB11 transports bile salts from cytosol to extracellular region - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2020-09-24
literatureReference	[LiteratureReference:192080] The enzymes, regulation, and genetics of bile acid synthesis
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
orthologousEvent	[Pathway:R-PFA-193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol - Plasmodium falciparum [Pathway:R-SCE-193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol - Saccharomyces cerevisiae [Pathway:R-SPO-193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol - Schizosaccharomyces pombe [Pathway:R-DDI-193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol - Dictyostelium discoideum [Pathway:R-CEL-193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol - Caenorhabditis elegans [Pathway:R-DME-193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol - Drosophila melanogaster [Pathway:R-GGA-193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol - Gallus gallus [Pathway:R-XTR-193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol - Xenopus tropicalis [Pathway:R-MMU-193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol - Mus musculus [Pathway:R-RNO-193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol - Rattus norvegicus [Pathway:R-CFA-193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol - Canis familiaris [Pathway:R-BTA-193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol - Bos taurus [Pathway:R-SSC-193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol - Sus scrofa [Pathway:R-DRE-193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol - Danio rerio
releaseDate	2007-05-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:197117] D'Eustachio, P, 2007-04-30 14:43:26
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-193368
summation	[Summation:193496] In the liver, synthesis of bile acids and bile salts is init...
updateTrackers	[UpdateTracker:9911017] Update Tracker - [Pathway:193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol - v89:[updateContainedRLE] [UpdateTracker:9780046] Update Tracker - [Pathway:193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol - v64:[updateContainedRLE] [UpdateTracker:9786541] Update Tracker - [Pathway:193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol - v49:[updateContainedRLE] [UpdateTracker:9790646] Update Tracker - [Pathway:193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol - v33:[updateContainedRLE] [UpdateTracker:9790077] Update Tracker - [Pathway:193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol - v35:[updateContainedRLE] [UpdateTracker:9789190] Update Tracker - [Pathway:193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol - v38:[addLiteratureReference] [UpdateTracker:9788793] Update Tracker - [Pathway:193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol - v40:[updateContainedRLE] [UpdateTracker:9786195] Update Tracker - [Pathway:193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol - v50:[updateContainedRLE] [UpdateTracker:9776812] Update Tracker - [Pathway:193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol - v74:[updateContainedRLE] [UpdateTracker:9790898] Update Tracker - [Pathway:193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol - v32:[updateContainedRLE] [UpdateTracker:9792368] Update Tracker - [Pathway:193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol - v22:[updateContainedRLE]

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[Pathway:R-HSA-192105] Synthesis of bile acids and bile salts

(updatedInstance)

[UpdateTracker:9911017] Update Tracker - [Pathway:193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol - v89:[updateContainedRLE]
[UpdateTracker:9780046] Update Tracker - [Pathway:193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol - v64:[updateContainedRLE]
[UpdateTracker:9786541] Update Tracker - [Pathway:193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol - v49:[updateContainedRLE]
[UpdateTracker:9790646] Update Tracker - [Pathway:193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol - v33:[updateContainedRLE]
[UpdateTracker:9790077] Update Tracker - [Pathway:193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol - v35:[updateContainedRLE]
[UpdateTracker:9789190] Update Tracker - [Pathway:193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol - v38:[addLiteratureReference]
[UpdateTracker:9788793] Update Tracker - [Pathway:193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol - v40:[updateContainedRLE]
[UpdateTracker:9786195] Update Tracker - [Pathway:193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol - v50:[updateContainedRLE]
[UpdateTracker:9776812] Update Tracker - [Pathway:193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol - v74:[updateContainedRLE]
[UpdateTracker:9790898] Update Tracker - [Pathway:193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol - v32:[updateContainedRLE]
[UpdateTracker:9792368] Update Tracker - [Pathway:193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol - v22:[updateContainedRLE]

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