Reactome | CYP8B1 12-hydroxylates 4CHOL7aOLONE

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CYP8B1 12-hydroxylates 4CHOL7aOLONE Show undefined attributes

authored	[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
catalystActivity	[CatalystActivity:192125] sterol 12-alpha-hydroxylase activity of CYP8B1 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:191989] Jassal, Bijay, 2007-01-26
crossReference	[DatabaseIdentifier:9907725] RHEA:46753
dbId	192157
displayName	CYP8B1 12-hydroxylates 4CHOL7aOLONE
edited	[InstanceEdit:193475] D'Eustachio, P, 2007-02-17 19:40:28
eventOf	[Pathway:R-HSA-193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol - Homo sapiens
followingEvent	[Reaction:R-HSA-192067] 4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one - Homo sapiens
input	[SimpleEntity:R-ALL-192136] 4CHOL7aOLONE [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:192101] Structure and chromosomal assignment of the sterol 12alpha-hydroxylase gene (CYP8B1) in human and mouse: eukaryotic cytochrome P-450 gene devoid of introns [LiteratureReference:5602286] Purification and characterization of 7 alpha-hydroxy-4-cholesten-3-one 12 alpha-hydroxylase
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	CYP8B1 12-hydroxylates 4CHOL7aOLONE 7alpha-hydroxycholest-4-en-3-one + O2 + reduced (NADPH--hemoprotein reductase) => 7alpha,12alpha-dihydroxycholest-4-en-3-one + H(+) + H2O + oxidized (NADPH--hemoprotein reductase) 4-Cholesten-7alpha-ol-3-one is 12alpha-hydroxylated to 7-alpha,12-alpha-dihydroxycholest-4-en-3-one 7-alpha-hydroxycholest-4-en-3-one + NADPH + H+ + O2 => 7-alpha,12-alpha-dihydroxycholest-4-en-3-one + NADP+ + H2O
orthologousEvent	[Reaction:R-GGA-192157] CYP8B1 12-hydroxylates 4CHOL7aOLONE - Gallus gallus [Reaction:R-XTR-192157] CYP8B1 12-hydroxylates 4CHOL7aOLONE - Xenopus tropicalis [Reaction:R-DRE-192157] CYP8B1 12-hydroxylates 4CHOL7aOLONE - Danio rerio [Reaction:R-SSC-192157] CYP8B1 12-hydroxylates 4CHOL7aOLONE - Sus scrofa [Reaction:R-CFA-192157] CYP8B1 12-hydroxylates 4CHOL7aOLONE - Canis familiaris [Reaction:R-RNO-192157] CYP8B1 12-hydroxylates 4CHOL7aOLONE - Rattus norvegicus [Reaction:R-MMU-192157] CYP8B1 12-hydroxylates 4CHOL7aOLONE - Mus musculus
output	[SimpleEntity:R-ALL-192195] 4CHOL7a,12aDONE [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[Reaction:R-HSA-192097] 7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one - Homo sapiens
releaseDate	2007-05-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:351775] D'Eustachio, P, 2008-05-28 08:30:54
revised	[InstanceEdit:5602271] Jassal, Bijay, 2014-06-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-192157
summation	[Summation:192122] Sterol 12alpha hydroxylase (CYP8B1), an enzyme associated wi...
updateTrackers	[UpdateTracker:9786297] Update Tracker - [Reaction:192157] CYP8B1 12-hydroxylates 4CHOL7aOLONE - v50:[addLiteratureReference, modifyText] [UpdateTracker:9910998] Update Tracker - [Reaction:192157] CYP8B1 12-hydroxylates 4CHOL7aOLONE - v89:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9786297] Update Tracker - [Reaction:192157] CYP8B1 12-hydroxylates 4CHOL7aOLONE - v50:[addLiteratureReference, modifyText] [UpdateTracker:9910998] Update Tracker - [Reaction:192157] CYP8B1 12-hydroxylates 4CHOL7aOLONE - v89:[modifyText]
(hasEvent)	[Pathway:R-HSA-193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol [Pathway:R-HSA-211994] Sterols are 12-hydroxylated by CYP8B1
(precedingEvent)	[Reaction:R-HSA-192067] 4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one

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