Reactome | 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA)

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3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) Show undefined attributes

authored	[InstanceEdit:191331] Jassal, Bijay, 2007-01-19
catalystActivity	[CatalystActivity:192037] steroid hydroxylase activity of CYP27A1 [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:193476] D'Eustachio, P, 2007-02-19 17:36:33
dbId	193460
displayName	3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA)
edited	[InstanceEdit:193475] D'Eustachio, P, 2007-02-17 19:40:28
eventOf	[Pathway:R-HSA-193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-193519] DHCA is translocated from the mitochondrial matrix to the cytosol - Homo sapiens
input	[SimpleEntity:R-ALL-193435] 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-113600] NADPH [mitochondrial matrix] [SimpleEntity:R-ALL-113533] O2 [mitochondrial matrix]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:192197] Characterization of human sterol 27-hydroxylase. A mitochondrial cytochrome P-450 that catalyzes multiple oxidation reaction in bile acid biosynthesis. [LiteratureReference:193375] Activities of recombinant human cytochrome P450c27 (CYP27) which produce intermediates of alternative bile acid biosynthetic pathways
maxDepth	1
modified	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
name	3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al + NADPH + H+ + O2 => 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) + NADP+ + H2O
orthologousEvent	[Reaction:R-DRE-193460] 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) - Danio rerio [Reaction:R-SSC-193460] 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) - Sus scrofa [Reaction:R-BTA-193460] 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) - Bos taurus [Reaction:R-CFA-193460] 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) - Canis familiaris [Reaction:R-RNO-193460] 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) - Rattus norvegicus [Reaction:R-MMU-193460] 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) - Mus musculus
output	[SimpleEntity:R-ALL-193440] DHCA [mitochondrial matrix] [SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix] [SimpleEntity:R-ALL-113563] NADP+ [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-193497] 5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al - Homo sapiens
releaseDate	2007-05-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:197117] D'Eustachio, P, 2007-04-30 14:43:26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-193460
summation	[Summation:193498] 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al, NADPH + H+, ...

Referrals

(hasEvent)	[Pathway:R-HSA-193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
(precedingEvent)	[BlackBoxEvent:R-HSA-193519] DHCA is translocated from the mitochondrial matrix to the cytosol

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