Reactome | 5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol

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5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol Show undefined attributes

authored	[InstanceEdit:191331] Jassal, Bijay, 2007-01-19
catalystActivity	[CatalystActivity:192098] alcohol dehydrogenase (NADP+) activity of Aldo-keto reductase family [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:191989] Jassal, Bijay, 2007-01-26
dbId	192036
displayName	5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol
edited	[InstanceEdit:193475] D'Eustachio, P, 2007-02-17 19:40:28
eventOf	[Pathway:R-HSA-193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol - Homo sapiens
followingEvent	[Reaction:R-HSA-192010] 5beta-cholestan-3alpha, 7alpha, 12alpha-triol is translocated from the cytosol to the mitochondrial matrix - Homo sapiens
input	[SimpleEntity:R-ALL-192064] 5beta-cholesten-7alpha, 12alpha-diol-3-one [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:192140] Human types 1 and 3 3 alpha-hydroxysteroid dehydrogenases: differential lability and tissue distribution
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol 5Beta-cholesten-7alpha, 12alpha-diol-3-one + NADPH + H+ => 5beta-cholestan-3alpha, 7alpha, 12alpha-triol + NAPDP+
orthologousEvent	[Reaction:R-SCE-192036] 5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol - Saccharomyces cerevisiae [Reaction:R-SPO-192036] 5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol - Schizosaccharomyces pombe [Reaction:R-DDI-192036] 5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol - Dictyostelium discoideum [Reaction:R-CEL-192036] 5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol - Caenorhabditis elegans [Reaction:R-DME-192036] 5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol - Drosophila melanogaster [Reaction:R-SSC-192036] 5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol - Sus scrofa [Reaction:R-BTA-192036] 5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol - Bos taurus [Reaction:R-CFA-192036] 5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol - Canis familiaris [Reaction:R-RNO-192036] 5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol - Rattus norvegicus [Reaction:R-MMU-192036] 5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol - Mus musculus
output	[SimpleEntity:R-ALL-192087] 5beta-cholestan-3alpha,7alpha,12alpha-triol [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[Reaction:R-HSA-192067] 4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one - Homo sapiens
releaseDate	2007-05-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:197117] D'Eustachio, P, 2007-04-30 14:43:26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-192036
summation	[Summation:193826] 5Beta-cholesten-7alpha,12alpha-diol-3-one and NADPH + H+ for...

Referrals

(hasEvent)	[Pathway:R-HSA-193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
(precedingEvent)	[Reaction:R-HSA-192010] 5beta-cholestan-3alpha, 7alpha, 12alpha-triol is translocated from the cytosol to the mitochondrial matrix

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