Reactome | CYP7A1 7-hydroxylates CHOL

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CYP7A1 7-hydroxylates CHOL Show undefined attributes

authored	[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
catalystActivity	[CatalystActivity:192120] cholesterol 7-alpha-monooxygenase activity of Cytochrome P450 (CYP7A1 based) [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:191989] Jassal, Bijay, 2007-01-26
crossReference	[DatabaseIdentifier:9907730] RHEA:21813
dbId	192051
displayName	CYP7A1 7-hydroxylates CHOL
edited	[InstanceEdit:193475] D'Eustachio, P, 2007-02-17 19:40:28
eventOf	[Pathway:R-HSA-193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol - Homo sapiens [Pathway:R-HSA-211976] Endogenous sterols - Homo sapiens
followingEvent	[Reaction:R-HSA-192097] 7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one - Homo sapiens
input	[SimpleEntity:R-ALL-193384] CHOL [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:192107] Molecular cloning and sequence analysis of cDNA encoding human cholesterol 7 alpha-hydroxylase
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	CYP7A1 7-hydroxylates CHOL cholesterol + O2 + reduced (NADPH--hemoprotein reductase) => 7alpha-hydroxycholesterol + H(+) + H2O + oxidized (NADPH--hemoprotein reductase) Cholesterol is hydroxylated to 7alpha-hydroxycholesterol by CYP7A1 Cholesterol + NADPH + H+ + O2 => 7-alpha-hydroxycholesterol + NADP+ + H2O
orthologousEvent	[Reaction:R-GGA-192051] CYP7A1 7-hydroxylates CHOL - Gallus gallus [Reaction:R-XTR-192051] CYP7A1 7-hydroxylates CHOL - Xenopus tropicalis [Reaction:R-DRE-192051] CYP7A1 7-hydroxylates CHOL - Danio rerio [Reaction:R-SSC-192051] CYP7A1 7-hydroxylates CHOL - Sus scrofa [Reaction:R-BTA-192051] CYP7A1 7-hydroxylates CHOL - Bos taurus [Reaction:R-CFA-192051] CYP7A1 7-hydroxylates CHOL - Canis familiaris [Reaction:R-RNO-192051] CYP7A1 7-hydroxylates CHOL - Rattus norvegicus [Reaction:R-MMU-192051] CYP7A1 7-hydroxylates CHOL - Mus musculus
output	[SimpleEntity:R-ALL-192114] 7 alpha-hydroxycholesterol [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[Reaction:R-HSA-5340195] NR1H4 binds DCA, CDCA, LCHA - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-5340416] Negative regulation by 'NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA [nucleoplasm]'
releaseDate	2007-05-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:351775] D'Eustachio, P, 2008-05-28 08:30:54
revised	[InstanceEdit:5602271] Jassal, Bijay, 2014-06-23 [InstanceEdit:5674206] Jassal, Bijay, 2015-02-11
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-192051
summation	[Summation:192159] Cholesterol, NADPH + H+, and O2 form 7alpha-cholesterol (5-c...
updateTrackers	[UpdateTracker:9786146] Update Tracker - [Reaction:192051] CYP7A1 7-hydroxylates CHOL - v50:[modifyText] [UpdateTracker:9786393] Update Tracker - [Reaction:192051] CYP7A1 7-hydroxylates CHOL - v49:[addRegulator]

Referrals

(updatedInstance)	[UpdateTracker:9786146] Update Tracker - [Reaction:192051] CYP7A1 7-hydroxylates CHOL - v50:[modifyText] [UpdateTracker:9786393] Update Tracker - [Reaction:192051] CYP7A1 7-hydroxylates CHOL - v49:[addRegulator]
(hasEvent)	[Pathway:R-HSA-193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol [Pathway:R-HSA-211976] Endogenous sterols
(precedingEvent)	[Reaction:R-HSA-192097] 7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one

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