Reactome | THCA is conjugated with Coenzyme A (SLC27A2 VLCS)

Schema > Reaction > Entries

THCA is conjugated with Coenzyme A (SLC27A2 VLCS) Show undefined attributes

authored	[InstanceEdit:191331] Jassal, Bijay, 2007-01-19
catalystActivity	[CatalystActivity:193506] long-chain fatty acid-CoA ligase activity of SLC27A2 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:193476] D'Eustachio, P, 2007-02-19 17:36:33
dbId	193401
displayName	THCA is conjugated with Coenzyme A (SLC27A2 VLCS)
edited	[InstanceEdit:193475] D'Eustachio, P, 2007-02-17 19:40:28
eventOf	[Pathway:R-HSA-193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-192325] 25(R) THCA-CoA is translocated from the cytosol to the peroxisome - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-76194] CoA-SH [cytosol] [SimpleEntity:R-ALL-192013] THCA [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:192044] Human liver-specific very-long-chain acyl-coenzyme A synthetase: cDNA cloning and characterization of a second enzymatically active protein [LiteratureReference:191995] The human liver-specific homolog of very long-chain acyl-CoA synthetase is cholate:CoA ligase [LiteratureReference:193432] Participation of two members of the very long-chain acyl-CoA synthetase family in bile acid synthesis and recycling
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	THCA is conjugated with Coenzyme A (SLC27A2 VLCS) THCA + ATP + CoASH => 25(R) THCA-CoA + AMP + pyrophosphate (SLC27A2 "VLCS")
orthologousEvent	[Reaction:R-CEL-193401] THCA is conjugated with Coenzyme A (SLC27A2 VLCS) - Caenorhabditis elegans [Reaction:R-DME-193401] THCA is conjugated with Coenzyme A (SLC27A2 VLCS) - Drosophila melanogaster [Reaction:R-GGA-193401] THCA is conjugated with Coenzyme A (SLC27A2 VLCS) - Gallus gallus [Reaction:R-XTR-193401] THCA is conjugated with Coenzyme A (SLC27A2 VLCS) - Xenopus tropicalis [Reaction:R-SSC-193401] THCA is conjugated with Coenzyme A (SLC27A2 VLCS) - Sus scrofa [Reaction:R-BTA-193401] THCA is conjugated with Coenzyme A (SLC27A2 VLCS) - Bos taurus [Reaction:R-CFA-193401] THCA is conjugated with Coenzyme A (SLC27A2 VLCS) - Canis familiaris [Reaction:R-RNO-193401] THCA is conjugated with Coenzyme A (SLC27A2 VLCS) - Rattus norvegicus [Reaction:R-MMU-193401] THCA is conjugated with Coenzyme A (SLC27A2 VLCS) - Mus musculus
output	[SimpleEntity:R-ALL-192096] 25(R) THCA-CoA [cytosol] [SimpleEntity:R-ALL-76577] AMP [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-191971] THCA is translocated from the mitochondrial matrix to the cytosol - Homo sapiens
releaseDate	2007-05-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:197117] D'Eustachio, P, 2007-04-30 14:43:26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-193401
summation	[Summation:193413] THCA (25(R) 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan...
updateTrackers	[UpdateTracker:9790535] Update Tracker - [Reaction:193401] THCA is conjugated with Coenzyme A (SLC27A2 VLCS) - v33:[modifyText, removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9790535] Update Tracker - [Reaction:193401] THCA is conjugated with Coenzyme A (SLC27A2 VLCS) - v33:[modifyText, removeOutput]
(hasEvent)	[Pathway:R-HSA-193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
(precedingEvent)	[BlackBoxEvent:R-HSA-192325] 25(R) THCA-CoA is translocated from the cytosol to the peroxisome