Reactome | Heme biosynthesis

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Heme biosynthesis Show undefined attributes

authored	[InstanceEdit:191749] Jassal, B, D'Eustachio, P, 2007-01-24 10:19:49
created	[InstanceEdit:189470] Jassal, B, 2006-11-20 11:41:56
dbId	189451
displayName	Heme biosynthesis
doi	10.3180/R-HSA-189451.5
edited	[InstanceEdit:191749] Jassal, B, D'Eustachio, P, 2007-01-24 10:19:49
eventOf	[Pathway:R-HSA-189445] Metabolism of porphyrins - Homo sapiens
figure	[Figure:189491] /figures/porphyrin_biosynthesis.jpg
goBiologicalProcess	[GO_BiologicalProcess:9907] heme biosynthetic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-189442] ALAS condenses SUCC-CoA and Gly to form dALA - Homo sapiens [BlackBoxEvent:R-HSA-189456] Mitochondrial dALA translocates to cytosol - Homo sapiens [Reaction:R-HSA-190141] ALAD binds to Pb2+ - Homo sapiens [Reaction:R-HSA-189439] ALAD condenses 2 dALAs to form PBG - Homo sapiens [Reaction:R-HSA-189406] 4 PBGs bind to form HMB - Homo sapiens [Reaction:R-HSA-189488] UROS transforms HMB to URO3 - Homo sapiens [Reaction:R-HSA-190168] HMBL spontaneously transforms to URO1 - Homo sapiens [Reaction:R-HSA-189425] UROD decarboxylates URO3 to COPRO3 - Homo sapiens [Reaction:R-HSA-190182] UROD decarboxylates URO1 to COPRO1 - Homo sapiens [BlackBoxEvent:R-HSA-189467] Cytosolic COPRO3 translocates to mitochondrial intermembrane space - Homo sapiens [Reaction:R-HSA-189421] CPO transforms COPRO3 to PPGEN9 - Homo sapiens [Reaction:R-HSA-189423] PPO oxidises PPGEN9 to PRIN9 - Homo sapiens [BlackBoxEvent:R-HSA-189457] Mitochondrial intermembrane PRIN9 translocates to mitochondrial matrix - Homo sapiens [Reaction:R-HSA-189465] FECH binds Fe2+ to PRIN9 to form heme - Homo sapiens [Reaction:R-HSA-9661408] FLVCR1-2 transports heme from mitochondrial matrix to cytosol - Homo sapiens [Reaction:R-HSA-917979] ABCG2 tetramer transports heme from cytosol to extracellular region - Homo sapiens [Reaction:R-HSA-917892] FLVCR1-1 transports heme from cytosol to extracellular region - Homo sapiens [Reaction:R-HSA-9661419] ALB binds extracellular heme - Homo sapiens [Reaction:R-HSA-2995330] COX10 transforms heme to heme O - Homo sapiens [Reaction:R-HSA-2995334] COX15 transforms heme O to heme A - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2019-12-10
literatureReference	[LiteratureReference:189403] Biosynthesis of heme in mammals [LiteratureReference:189501] Cell biology of heme [LiteratureReference:9663478] Structure and function of enzymes in heme biosynthesis [LiteratureReference:9663482] [Porphyrias and haem related disorders]
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Heme biosynthesis
orthologousEvent	[Pathway:R-RNO-189451] Heme biosynthesis - Rattus norvegicus [Pathway:R-MMU-189451] Heme biosynthesis - Mus musculus [Pathway:R-CFA-189451] Heme biosynthesis - Canis familiaris [Pathway:R-BTA-189451] Heme biosynthesis - Bos taurus [Pathway:R-SSC-189451] Heme biosynthesis - Sus scrofa [Pathway:R-DRE-189451] Heme biosynthesis - Danio rerio [Pathway:R-XTR-189451] Heme biosynthesis - Xenopus tropicalis [Pathway:R-GGA-189451] Heme biosynthesis - Gallus gallus [Pathway:R-DME-189451] Heme biosynthesis - Drosophila melanogaster [Pathway:R-CEL-189451] Heme biosynthesis - Caenorhabditis elegans [Pathway:R-DDI-189451] Heme biosynthesis - Dictyostelium discoideum [Pathway:R-SPO-189451] Heme biosynthesis - Schizosaccharomyces pombe [Pathway:R-SCE-189451] Heme biosynthesis - Saccharomyces cerevisiae [Pathway:R-PFA-189451] Heme biosynthesis - Plasmodium falciparum
releaseDate	2007-02-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:191750] Sassa, S, 2007-01-24 10:18:36
revised	[InstanceEdit:421639] D'Eustachio, P, 2009-05-19 13:25:07 [InstanceEdit:9661807] Jassal, Bijay, 2019-09-18 [InstanceEdit:9854168] D'Eustachio, Peter, 2023-11-22
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-189451
summation	[Summation:189440] Although heme is synthesised in virtually all tissues, the p...
updateTrackers	[UpdateTracker:9777498] Update Tracker - [Pathway:189451] Heme biosynthesis - v71:[addHasEvent, addLiteratureReference, modifyText, updateContainedRLE] [UpdateTracker:9791570] Update Tracker - [Pathway:189451] Heme biosynthesis - v28:[updateContainedRLE] [UpdateTracker:9788092] Update Tracker - [Pathway:189451] Heme biosynthesis - v44:[updateContainedRLE] [UpdateTracker:9781021] Update Tracker - [Pathway:189451] Heme biosynthesis - v61:[updateContainedRLE] [UpdateTracker:9787432] Update Tracker - [Pathway:189451] Heme biosynthesis - v45:[addHasEvent] [UpdateTracker:9777711] Update Tracker - [Pathway:189451] Heme biosynthesis - v69:[updateContainedRLE] [UpdateTracker:9790175] Update Tracker - [Pathway:189451] Heme biosynthesis - v35:[updateContainedRLE] [UpdateTracker:9864196] Update Tracker - [Pathway:189451] Heme biosynthesis - v88:[updateContainedRLE] [UpdateTracker:9911094] Update Tracker - [Pathway:189451] Heme biosynthesis - v89:[updateContainedRLE]

Referrals

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[Pathway:R-HSA-189445] Metabolism of porphyrins

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