Reactome | ALAS condenses SUCC-CoA and Gly to form dALA

Schema > Reaction > Entries

ALAS condenses SUCC-CoA and Gly to form dALA Show undefined attributes

authored	[InstanceEdit:191749] Jassal, B, D'Eustachio, P, 2007-01-24 10:19:49
catalystActivity	[CatalystActivity:189479] 5-aminolevulinate synthase activity of ALAS1,2 [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:189470] Jassal, B, 2006-11-20 11:41:56
crossReference	[DatabaseIdentifier:11880805] Rhea:12922
dbId	189442
displayName	ALAS condenses SUCC-CoA and Gly to form dALA
edited	[InstanceEdit:191749] Jassal, B, D'Eustachio, P, 2007-01-24 10:19:49
eventOf	[Pathway:R-HSA-189451] Heme biosynthesis - Homo sapiens
followingEvent	[Reaction:R-HSA-189456] Mitochondrial dALA translocates to cytosol - Homo sapiens
input	[SimpleEntity:R-ALL-159549] Gly [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-70958] SUCC-CoA [mitochondrial matrix]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:189502] Biosynthesis of delta-aminolevulinic acid and the regulation of heme formation by immature erythroid cells in man [LiteratureReference:190160] Crystal structure of 5-aminolevulinate synthase, the first enzyme of heme biosynthesis, and its link to XLSA in humans
modified	[InstanceEdit:11879863] Wright, Adam, 2024-03-11
name	ALAS condenses SUCC-CoA and Gly to form dALA glycine + H(+) + succinyl-CoA => 5-aminolevulinate + CO2 + CoA Succinyl CoA and glycine condense to form 5-aminolevulinate (ALA)
orthologousEvent	[Reaction:R-PFA-189442] ALAS condenses SUCC-CoA and Gly to form dALA - Plasmodium falciparum [Reaction:R-SCE-189442] ALAS condenses SUCC-CoA and Gly to form dALA - Saccharomyces cerevisiae [Reaction:R-SPO-189442] ALAS condenses SUCC-CoA and Gly to form dALA - Schizosaccharomyces pombe [Reaction:R-DDI-189442] ALAS condenses SUCC-CoA and Gly to form dALA - Dictyostelium discoideum [Reaction:R-DME-189442] ALAS condenses SUCC-CoA and Gly to form dALA - Drosophila melanogaster [Reaction:R-GGA-189442] ALAS condenses SUCC-CoA and Gly to form dALA - Gallus gallus [Reaction:R-XTR-189442] ALAS condenses SUCC-CoA and Gly to form dALA - Xenopus tropicalis [Reaction:R-DRE-189442] ALAS condenses SUCC-CoA and Gly to form dALA - Danio rerio [Reaction:R-SSC-189442] ALAS condenses SUCC-CoA and Gly to form dALA - Sus scrofa [Reaction:R-BTA-189442] ALAS condenses SUCC-CoA and Gly to form dALA - Bos taurus [Reaction:R-CFA-189442] ALAS condenses SUCC-CoA and Gly to form dALA - Canis familiaris [Reaction:R-RNO-189442] ALAS condenses SUCC-CoA and Gly to form dALA - Rattus norvegicus [Reaction:R-MMU-189442] ALAS condenses SUCC-CoA and Gly to form dALA - Mus musculus
output	[SimpleEntity:R-ALL-29376] CO2 [mitochondrial matrix] [SimpleEntity:R-ALL-29374] CoA-SH [mitochondrial matrix] [SimpleEntity:R-ALL-189466] dALA [mitochondrial matrix]
regulatedBy	[NegativeRegulation:R-HSA-189417] Negative regulation by 'heme [mitochondrial matrix]'
releaseDate	2007-02-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:191750] Sassa, S, 2007-01-24 10:18:36
revised	[InstanceEdit:421639] D'Eustachio, P, 2009-05-19 13:25:07 [InstanceEdit:9854168] D'Eustachio, Peter, 2023-11-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-189442
summation	[Summation:189409] The committed step for porphyrin synthesis is the formation ...

Referrals

(precedingEvent)	[Reaction:R-HSA-189456] Mitochondrial dALA translocates to cytosol
(hasEvent)	[Pathway:R-HSA-189451] Heme biosynthesis