Reactome | 4 PBGs bind to form HMB

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4 PBGs bind to form HMB Show undefined attributes

authored	[InstanceEdit:191749] Jassal, B, D'Eustachio, P, 2007-01-24 10:19:49
catalystActivity	[CatalystActivity:189486] hydroxymethylbilane synthase activity of HMBS:DIPY [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:189470] Jassal, B, 2006-11-20 11:41:56
crossReference	[DatabaseIdentifier:11881243] Rhea:13186
dbId	189406
displayName	4 PBGs bind to form HMB
edited	[InstanceEdit:191749] Jassal, B, D'Eustachio, P, 2007-01-24 10:19:49
eventOf	[Pathway:R-HSA-189451] Heme biosynthesis - Homo sapiens
followingEvent	[Reaction:R-HSA-189488] UROS transforms HMB to URO3 - Homo sapiens [Reaction:R-HSA-190168] HMBL spontaneously transforms to URO1 - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] 4 × [SimpleEntity:R-ALL-189464] PBG [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:189990] Human porphobilinogen deaminase mutations in the investigation of the mechanism of dipyrromethane cofactor assembly and tetrapyrrole formation [LiteratureReference:190139] Purification and properties of uroporphyrinogen I synthase from human erythrocytes. Identification of stable enzyme-substrate intermediates.
modified	[InstanceEdit:11879863] Wright, Adam, 2024-03-11
name	4 PBGs bind to form HMB H2O + 4 porphobilinogen => hydroxymethylbilane + 4 NH4(+) Four PBGs combine through deamination to form hydroxymethylbilane (HMB)
orthologousEvent	[Reaction:R-GGA-421439] 4 porphobilinogen + H2O => hydroxymethylbilane + 4 NH3 - Gallus gallus [Reaction:R-PFA-189406] 4 PBGs bind to form HMB - Plasmodium falciparum [Reaction:R-SCE-189406] 4 PBGs bind to form HMB - Saccharomyces cerevisiae [Reaction:R-SPO-189406] 4 PBGs bind to form HMB - Schizosaccharomyces pombe [Reaction:R-DME-189406] 4 PBGs bind to form HMB - Drosophila melanogaster [Reaction:R-GGA-189406] 4 PBGs bind to form HMB - Gallus gallus [Reaction:R-XTR-189406] 4 PBGs bind to form HMB - Xenopus tropicalis [Reaction:R-SSC-189406] 4 PBGs bind to form HMB - Sus scrofa [Reaction:R-BTA-189406] 4 PBGs bind to form HMB - Bos taurus [Reaction:R-CFA-189406] 4 PBGs bind to form HMB - Canis familiaris [Reaction:R-RNO-189406] 4 PBGs bind to form HMB - Rattus norvegicus [Reaction:R-MMU-189406] 4 PBGs bind to form HMB - Mus musculus
output	[SimpleEntity:R-ALL-189449] HMBL [cytosol] 4 × [SimpleEntity:R-ALL-31633] NH4+ [cytosol]
precedingEvent	[Reaction:R-HSA-189439] ALAD condenses 2 dALAs to form PBG - Homo sapiens
releaseDate	2007-02-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:191750] Sassa, S, 2007-01-24 10:18:36
revised	[InstanceEdit:421639] D'Eustachio, P, 2009-05-19 13:25:07 [InstanceEdit:9854168] D'Eustachio, Peter, 2023-11-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-189406
summation	[Summation:189477] Cytosolic porphobilinogen deaminase catalyzes the polymeriza...

Referrals

(hasEvent)	[Pathway:R-HSA-189451] Heme biosynthesis
(precedingEvent)	[Reaction:R-HSA-189488] UROS transforms HMB to URO3 [Reaction:R-HSA-190168] HMBL spontaneously transforms to URO1