Reactome | UROD decarboxylates URO3 to COPRO3

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UROD decarboxylates URO3 to COPRO3 Show undefined attributes

authored	[InstanceEdit:191749] Jassal, B, D'Eustachio, P, 2007-01-24 10:19:49
catalystActivity	[CatalystActivity:189412] carbon-carbon lyase activity of 2xUROD [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:189470] Jassal, B, 2006-11-20 11:41:56
crossReference	[DatabaseIdentifier:12668027] RHEA:19866
dbId	189425
displayName	UROD decarboxylates URO3 to COPRO3
edited	[InstanceEdit:191749] Jassal, B, D'Eustachio, P, 2007-01-24 10:19:49
eventOf	[Pathway:R-HSA-189451] Heme biosynthesis - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-189467] Cytosolic COPRO3 translocates to mitochondrial intermembrane space - Homo sapiens
input	4 × [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-189407] URO3 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:190134] Purification and properties of uroporphyrinogen decarboxylase from human erythrocytes. A single enzyme catalyzing the four sequential decarboxylations of uroporphyrinogens I and III. [LiteratureReference:190137] Uroporphyrinogen decarboxylase: complete human gene sequence and molecular study of three families with hepatoerythropoietic porphyria
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	UROD decarboxylates URO3 to COPRO3 4 H(+) + uroporphyrinogen III => 4 CO2 + coproporphyrinogen III Uroporphyrinogen III is decarboxylated to form coproporphyrinogen III
orthologousEvent	[Reaction:R-GGA-421515] uroporphyrinogen III => coproporphyrinogen III + 4 CO2 - Gallus gallus [Reaction:R-PFA-189425] UROD decarboxylates URO3 to COPRO3 - Plasmodium falciparum [Reaction:R-SCE-189425] UROD decarboxylates URO3 to COPRO3 - Saccharomyces cerevisiae [Reaction:R-SPO-189425] UROD decarboxylates URO3 to COPRO3 - Schizosaccharomyces pombe [Reaction:R-DDI-189425] UROD decarboxylates URO3 to COPRO3 - Dictyostelium discoideum [Reaction:R-DME-189425] UROD decarboxylates URO3 to COPRO3 - Drosophila melanogaster [Reaction:R-GGA-189425] UROD decarboxylates URO3 to COPRO3 - Gallus gallus [Reaction:R-XTR-189425] UROD decarboxylates URO3 to COPRO3 - Xenopus tropicalis [Reaction:R-DRE-189425] UROD decarboxylates URO3 to COPRO3 - Danio rerio [Reaction:R-SSC-189425] UROD decarboxylates URO3 to COPRO3 - Sus scrofa [Reaction:R-BTA-189425] UROD decarboxylates URO3 to COPRO3 - Bos taurus [Reaction:R-CFA-189425] UROD decarboxylates URO3 to COPRO3 - Canis familiaris [Reaction:R-RNO-189425] UROD decarboxylates URO3 to COPRO3 - Rattus norvegicus [Reaction:R-MMU-189425] UROD decarboxylates URO3 to COPRO3 - Mus musculus
output	4 × [SimpleEntity:R-ALL-113528] CO2 [cytosol] [SimpleEntity:R-ALL-189455] COPRO3 [cytosol]
precedingEvent	[Reaction:R-HSA-189488] UROS transforms HMB to URO3 - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2007-02-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:191750] Sassa, S, 2007-01-24 10:18:36 [InstanceEdit:9861359] Hill, David P, 2024-02-16
revised	[InstanceEdit:421639] D'Eustachio, P, 2009-05-19 13:25:07 [InstanceEdit:9854168] D'Eustachio, Peter, 2023-11-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-189425
summation	[Summation:189490] Cytosolic uroporphyrinogen decarboxylase (UROD) catalyzes th...
updateTrackers	[UpdateTracker:9864257] Update Tracker - [Reaction:189425] UROD decarboxylates URO3 to COPRO3 - v88:[addInput] [UpdateTracker:9787902] Update Tracker - [Reaction:189425] UROD decarboxylates URO3 to COPRO3 - v44:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9864257] Update Tracker - [Reaction:189425] UROD decarboxylates URO3 to COPRO3 - v88:[addInput] [UpdateTracker:9787902] Update Tracker - [Reaction:189425] UROD decarboxylates URO3 to COPRO3 - v44:[modifyText]
(hasEvent)	[Pathway:R-HSA-189451] Heme biosynthesis
(precedingEvent)	[BlackBoxEvent:R-HSA-189467] Cytosolic COPRO3 translocates to mitochondrial intermembrane space