Reactome | CPO transforms COPRO3 to PPGEN9

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CPO transforms COPRO3 to PPGEN9 Show undefined attributes

authored	[InstanceEdit:191749] Jassal, B, D'Eustachio, P, 2007-01-24 10:19:49
catalystActivity	[CatalystActivity:189416] coproporphyrinogen oxidase activity of 2xCPO [mitochondrial intermembrane space]
catalystActivityReference	[CatalystActivityReference:9853721] coproporphyrinogen oxidase activity of 2xCPO [mitochondrial intermembrane space] Molecular cloning, sequencing, and functional expression of a cDNA encoding human coproporphyrinogen oxidase
category	transition
compartment	[Compartment:17927] mitochondrial intermembrane space
created	[InstanceEdit:189470] Jassal, B, 2006-11-20 11:41:56
crossReference	[DatabaseIdentifier:12668026] RHEA:18258
dbId	189421
displayName	CPO transforms COPRO3 to PPGEN9
edited	[InstanceEdit:191749] Jassal, B, D'Eustachio, P, 2007-01-24 10:19:49
eventOf	[Pathway:R-HSA-189451] Heme biosynthesis - Homo sapiens
followingEvent	[Reaction:R-HSA-189423] PPO oxidises PPGEN9 to PRIN9 - Homo sapiens
input	[SimpleEntity:R-ALL-189411] COPRO3 [mitochondrial intermembrane space] [SimpleEntity:R-ALL-163953] H+ [mitochondrial intermembrane space] [SimpleEntity:R-ALL-189461] O2 [mitochondrial intermembrane space]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:190006] Kinetic evaluation of human cloned coproporphyrinogen oxidase using a ring isomer of the natural substrate [LiteratureReference:190133] Evidence that the coproporphyrinogen oxidase activity of rat liver is situated in the intermembrane space of mitochondria [LiteratureReference:190177] Structural basis of hereditary coproporphyria [LiteratureReference:9853720] Molecular cloning, sequencing, and functional expression of a cDNA encoding human coproporphyrinogen oxidase
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	CPO transforms COPRO3 to PPGEN9 coproporphyrinogen III + 2 H(+) + O2 => 2 CO2 + 2 H2O + protoporphyrinogen IX Conversion of coproporphyrinogen III to protoporphyrinogen IX
orthologousEvent	[Reaction:R-GGA-421478] coproporphyrinogen III + 2 O2 => protoporphyrinogen IX + 2 H2O2 + 2 CO2 - Gallus gallus [Reaction:R-PFA-189421] CPO transforms COPRO3 to PPGEN9 - Plasmodium falciparum [Reaction:R-SCE-189421] CPO transforms COPRO3 to PPGEN9 - Saccharomyces cerevisiae [Reaction:R-SPO-189421] CPO transforms COPRO3 to PPGEN9 - Schizosaccharomyces pombe [Reaction:R-DDI-189421] CPO transforms COPRO3 to PPGEN9 - Dictyostelium discoideum [Reaction:R-DME-189421] CPO transforms COPRO3 to PPGEN9 - Drosophila melanogaster [Reaction:R-GGA-189421] CPO transforms COPRO3 to PPGEN9 - Gallus gallus [Reaction:R-XTR-189421] CPO transforms COPRO3 to PPGEN9 - Xenopus tropicalis [Reaction:R-DRE-189421] CPO transforms COPRO3 to PPGEN9 - Danio rerio [Reaction:R-SSC-189421] CPO transforms COPRO3 to PPGEN9 - Sus scrofa [Reaction:R-BTA-189421] CPO transforms COPRO3 to PPGEN9 - Bos taurus [Reaction:R-CFA-189421] CPO transforms COPRO3 to PPGEN9 - Canis familiaris [Reaction:R-RNO-189421] CPO transforms COPRO3 to PPGEN9 - Rattus norvegicus [Reaction:R-MMU-189421] CPO transforms COPRO3 to PPGEN9 - Mus musculus
output	2 × [SimpleEntity:R-ALL-189480] CO2 [mitochondrial intermembrane space] [SimpleEntity:R-ALL-189422] H2O [mitochondrial intermembrane space] [SimpleEntity:R-ALL-189478] PPGEN9 [mitochondrial intermembrane space]
precedingEvent	[BlackBoxEvent:R-HSA-189467] Cytosolic COPRO3 translocates to mitochondrial intermembrane space - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2007-02-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:191750] Sassa, S, 2007-01-24 10:18:36 [InstanceEdit:9861359] Hill, David P, 2024-02-16
revised	[InstanceEdit:421639] D'Eustachio, P, 2009-05-19 13:25:07 [InstanceEdit:9854168] D'Eustachio, Peter, 2023-11-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-189421
summation	[Summation:189418] O2-dependent coproporpyrinogen oxidase (CPO) catalyzes the c...
updateTrackers	[UpdateTracker:9863974] Update Tracker - [Reaction:189421] CPO transforms COPRO3 to PPGEN9 - v88:[addInput, addLiteratureReference, add_removeOutput, modifyText] [UpdateTracker:9787685] Update Tracker - [Reaction:189421] CPO transforms COPRO3 to PPGEN9 - v44:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9863974] Update Tracker - [Reaction:189421] CPO transforms COPRO3 to PPGEN9 - v88:[addInput, addLiteratureReference, add_removeOutput, modifyText] [UpdateTracker:9787685] Update Tracker - [Reaction:189421] CPO transforms COPRO3 to PPGEN9 - v44:[modifyText]
(hasEvent)	[Pathway:R-HSA-189451] Heme biosynthesis
(precedingEvent)	[Reaction:R-HSA-189423] PPO oxidises PPGEN9 to PRIN9

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