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Schema
>
Reaction
>
Entries
ABCG2 tetramer transports heme from cytosol to extracellular region
Show undefined attributes
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authored
[InstanceEdit:917867] Stephan, R, 2010-07-07
catalystActivity
[CatalystActivity:917884] ABC-type heme transporter activity of ABCG2 tetramer [plasma membrane]
category
transition
compartment
[Compartment:876] plasma membrane
created
[InstanceEdit:917843] Jassal, Bijay, 2010-07-30
crossReference
[DatabaseIdentifier:12667904] RHEA:19261
dbId
917979
displayName
ABCG2 tetramer transports heme from cytosol to extracellular region
edited
[InstanceEdit:917843] Jassal, Bijay, 2010-07-30
eventOf
[Pathway:R-HSA-917937] Iron uptake and transport - Homo sapiens
[Pathway:R-HSA-189451] Heme biosynthesis - Homo sapiens
followingEvent
[Reaction:R-HSA-9661419] ALB binds extracellular heme - Homo sapiens
input
[SimpleEntity:R-ALL-113592] ATP [cytosol]
[SimpleEntity:R-ALL-71185] ferroheme [cytosol]
[SimpleEntity:R-ALL-29356] H2O [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:9661436] Characterization of oligomeric human half-ABC transporter ATP-binding cassette G2
[LiteratureReference:917942] The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme
[LiteratureReference:917914] Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2)
[LiteratureReference:994083] The expression and functional characterization of ABCG2 in brain endothelial cells and vessels
maxDepth
1
modified
[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name
ABCG2 tetramer transports heme from cytosol to extracellular region
ATP + H2O + heme b(in) => ADP + H(+) + heme b(out) + phosphate
Export of heme to the blood by ABCG2
orthologousEvent
[Reaction:R-PFA-917979] ABCG2 tetramer transports heme from cytosol to extracellular region - Plasmodium falciparum
[Reaction:R-DDI-917979] ABCG2 tetramer transports heme from cytosol to extracellular region - Dictyostelium discoideum
[Reaction:R-CEL-917979] ABCG2 tetramer transports heme from cytosol to extracellular region - Caenorhabditis elegans
[Reaction:R-DME-917979] ABCG2 tetramer transports heme from cytosol to extracellular region - Drosophila melanogaster
[Reaction:R-XTR-917979] ABCG2 tetramer transports heme from cytosol to extracellular region - Xenopus tropicalis
[Reaction:R-SSC-917979] ABCG2 tetramer transports heme from cytosol to extracellular region - Sus scrofa
[Reaction:R-BTA-917979] ABCG2 tetramer transports heme from cytosol to extracellular region - Bos taurus
[Reaction:R-CFA-917979] ABCG2 tetramer transports heme from cytosol to extracellular region - Canis familiaris
[Reaction:R-RNO-917979] ABCG2 tetramer transports heme from cytosol to extracellular region - Rattus norvegicus
[Reaction:R-MMU-917979] ABCG2 tetramer transports heme from cytosol to extracellular region - Mus musculus
output
[SimpleEntity:R-ALL-29370] ADP [cytosol]
[SimpleEntity:R-ALL-70106] H+ [cytosol]
[SimpleEntity:R-ALL-917877] heme [extracellular region]
[SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent
[Reaction:R-HSA-9661408] FLVCR1-2 transports heme from mitochondrial matrix to cytosol - Homo sapiens
previousReviewStatus
[ReviewStatus:9821384] two stars
releaseDate
2010-12-14
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:994085] D'Eustachio, P, 2010-11-05
[InstanceEdit:9861286] Hill, David P, 2024-02-16
revised
[InstanceEdit:9661807] Jassal, Bijay, 2019-09-18
[InstanceEdit:9854168] D'Eustachio, Peter, 2023-11-22
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-917979
summation
[Summation:917908] Heme is utilised as a prosthetic group in the production of ...
updateTrackers
[UpdateTracker:9864333] Update Tracker - [Reaction:917979] ABCG2 tetramer transports heme from cytosol to extracellular region - v88:[addOutput]
[UpdateTracker:9777410] Update Tracker - [Reaction:917979] ABCG2 tetramer transports heme from cytosol to extracellular region - v71:[addLiteratureReference, modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9864333] Update Tracker - [Reaction:917979] ABCG2 tetramer transports heme from cytosol to extracellular region - v88:[addOutput]
[UpdateTracker:9777410] Update Tracker - [Reaction:917979] ABCG2 tetramer transports heme from cytosol to extracellular region - v71:[addLiteratureReference, modifyText]
(hasEvent)
[Pathway:R-HSA-189451] Heme biosynthesis
[Pathway:R-HSA-917937] Iron uptake and transport
(precedingEvent)
[Reaction:R-HSA-9661419] ALB binds extracellular heme
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