Reactome | ALAD condenses 2 dALAs to form PBG

Schema > Reaction > Entries

ALAD condenses 2 dALAs to form PBG Show undefined attributes

authored	[InstanceEdit:191749] Jassal, B, D'Eustachio, P, 2007-01-24 10:19:49
catalystActivity	[CatalystActivity:189415] porphobilinogen synthase activity of 8x(ALAD:Zn2+) [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:189470] Jassal, B, 2006-11-20 11:41:56
crossReference	[DatabaseIdentifier:12668030] RHEA:24065
dbId	189439
deleted	[Deleted:190195] Deletion of instance: 189989
displayName	ALAD condenses 2 dALAs to form PBG
edited	[InstanceEdit:191749] Jassal, B, D'Eustachio, P, 2007-01-24 10:19:49
eventOf	[Pathway:R-HSA-189451] Heme biosynthesis - Homo sapiens
followingEvent	[Reaction:R-HSA-189406] 4 PBGs bind to form HMB - Homo sapiens
input	2 × [SimpleEntity:R-ALL-189489] dALA [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:190123] Mechanistic implications of mutations to the active site lysine of porphobilinogen synthase [LiteratureReference:190163] Novel molecular defects of the delta-aminolevulinate dehydratase gene in a patient with inherited acute hepatic porphyria
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	ALAD condenses 2 dALAs to form PBG 2 5-aminolevulinate => H(+) + 2 H2O + porphobilinogen Two molecules of ALA condense to form porphobilinogen (PBG)
orthologousEvent	[Reaction:R-GGA-421472] 2 delta-aminolevulinate => porphobilinogen + 2 H2O - Gallus gallus [Reaction:R-PFA-189439] ALAD condenses 2 dALAs to form PBG - Plasmodium falciparum [Reaction:R-SCE-189439] ALAD condenses 2 dALAs to form PBG - Saccharomyces cerevisiae [Reaction:R-SPO-189439] ALAD condenses 2 dALAs to form PBG - Schizosaccharomyces pombe [Reaction:R-DDI-189439] ALAD condenses 2 dALAs to form PBG - Dictyostelium discoideum [Reaction:R-DME-189439] ALAD condenses 2 dALAs to form PBG - Drosophila melanogaster [Reaction:R-GGA-189439] ALAD condenses 2 dALAs to form PBG - Gallus gallus [Reaction:R-XTR-189439] ALAD condenses 2 dALAs to form PBG - Xenopus tropicalis [Reaction:R-DRE-189439] ALAD condenses 2 dALAs to form PBG - Danio rerio [Reaction:R-SSC-189439] ALAD condenses 2 dALAs to form PBG - Sus scrofa [Reaction:R-BTA-189439] ALAD condenses 2 dALAs to form PBG - Bos taurus [Reaction:R-CFA-189439] ALAD condenses 2 dALAs to form PBG - Canis familiaris [Reaction:R-RNO-189439] ALAD condenses 2 dALAs to form PBG - Rattus norvegicus [Reaction:R-MMU-189439] ALAD condenses 2 dALAs to form PBG - Mus musculus
output	[SimpleEntity:R-ALL-70106] H+ [cytosol] 2 × [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-189464] PBG [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-189456] Mitochondrial dALA translocates to cytosol - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
regulatedBy	[NegativeRegulation:9853728] Negative regulation by '8xALAD:Pb2+:Zn2+ [cytosol]'
regulationReference	[RegulationReference:9853723] Negative regulation by '8xALAD:Pb2+:Zn2+ [cytosol]' The molecular mechanism of lead inhibition of human porphobilinogen synthase
releaseDate	2007-02-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:191750] Sassa, S, 2007-01-24 10:18:36 [InstanceEdit:9861359] Hill, David P, 2024-02-16
revised	[InstanceEdit:421639] D'Eustachio, P, 2009-05-19 13:25:07 [InstanceEdit:9854168] D'Eustachio, Peter, 2023-11-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-189439
summation	[Summation:189413] 5-Aminolevulinic acid dehydratase (ALAD aka porphobilinogen ...
updateTrackers	[UpdateTracker:9863951] Update Tracker - [Reaction:189439] ALAD condenses 2 dALAs to form PBG - v88:[addRegulator] [UpdateTracker:9788046] Update Tracker - [Reaction:189439] ALAD condenses 2 dALAs to form PBG - v44:[modifyText] [UpdateTracker:9777710] Update Tracker - [Reaction:189439] ALAD condenses 2 dALAs to form PBG - v69:[addOutput]

Referrals

(updatedInstance)	[UpdateTracker:9863951] Update Tracker - [Reaction:189439] ALAD condenses 2 dALAs to form PBG - v88:[addRegulator] [UpdateTracker:9788046] Update Tracker - [Reaction:189439] ALAD condenses 2 dALAs to form PBG - v44:[modifyText] [UpdateTracker:9777710] Update Tracker - [Reaction:189439] ALAD condenses 2 dALAs to form PBG - v69:[addOutput]
(replacementInstances)	[Deleted:190195] Deletion of instance: 189989
(hasEvent)	[Pathway:R-HSA-189451] Heme biosynthesis
(precedingEvent)	[Reaction:R-HSA-189406] 4 PBGs bind to form HMB