Reactome | COX10 transforms heme to heme O

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COX10 transforms heme to heme O Show undefined attributes

authored	[InstanceEdit:2995335] Jassal, B, 2013-01-22
catalystActivity	[CatalystActivity:2995336] protoheme IX farnesyltransferase activity of COX10(?-443) [mitochondrial inner membrane]
category	transition
compartment	[Compartment:5460] mitochondrial matrix [Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:2995335] Jassal, B, 2013-01-22
dbId	2995330
displayName	COX10 transforms heme to heme O
edited	[InstanceEdit:2995335] Jassal, B, 2013-01-22
eventOf	[Pathway:R-HSA-189451] Heme biosynthesis - Homo sapiens
followingEvent	[Reaction:R-HSA-2995334] COX15 transforms heme O to heme A - Homo sapiens
input	[SimpleEntity:R-ALL-2162257] FPP [mitochondrial matrix] [SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix] [SimpleEntity:R-ALL-9853511] heme b [mitochondrial inner membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2995324] Isolation of a human cDNA for heme A:farnesyltransferase by functional complementation of a yeast cox10 mutant [LiteratureReference:2995351] Genomic structure and expression of the human heme A:farnesyltransferase (COX10) gene [LiteratureReference:9854158] Biosynthesis and trafficking of heme o and heme a: new structural insights and their implications for reaction mechanisms and prenylated heme transfer
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	COX10 transforms heme to heme O (2E,6E)-farnesyl diphosphate + H2O + heme b => diphosphate + Fe(II)-heme o
orthologousEvent	[Reaction:R-RNO-2995330] COX10 transforms heme to heme O - Rattus norvegicus [Reaction:R-PFA-2995330] COX10 transforms heme to heme O - Plasmodium falciparum [Reaction:R-SCE-2995330] COX10 transforms heme to heme O - Saccharomyces cerevisiae [Reaction:R-SPO-2995330] COX10 transforms heme to heme O - Schizosaccharomyces pombe [Reaction:R-DDI-2995330] COX10 transforms heme to heme O - Dictyostelium discoideum [Reaction:R-CEL-2995330] COX10 transforms heme to heme O - Caenorhabditis elegans [Reaction:R-DME-2995330] COX10 transforms heme to heme O - Drosophila melanogaster [Reaction:R-GGA-2995330] COX10 transforms heme to heme O - Gallus gallus [Reaction:R-XTR-2995330] COX10 transforms heme to heme O - Xenopus tropicalis [Reaction:R-DRE-2995330] COX10 transforms heme to heme O - Danio rerio [Reaction:R-SSC-2995330] COX10 transforms heme to heme O - Sus scrofa [Reaction:R-BTA-2995330] COX10 transforms heme to heme O - Bos taurus [Reaction:R-CFA-2995330] COX10 transforms heme to heme O - Canis familiaris [Reaction:R-MMU-2995330] COX10 transforms heme to heme O - Mus musculus
output	[SimpleEntity:R-ALL-9865393] heme O [mitochondrial inner membrane] [SimpleEntity:R-ALL-159450] PPi [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-189465] FECH binds Fe2+ to PRIN9 to form heme - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2013-06-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3288227] D'Eustachio, P, 2013-04-15 [InstanceEdit:9865397] Matthews, Lisa, 2024-03-11
revised	[InstanceEdit:9854168] D'Eustachio, Peter, 2023-11-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2995330
summation	[Summation:2995359] Heme A and less frequently heme O function as prosthetic gro...
updateTrackers	[UpdateTracker:9864334] Update Tracker - [Reaction:2995330] COX10 transforms heme to heme O - v88:[addLiteratureReference, modifyText] [UpdateTracker:9911033] Update Tracker - [Reaction:2995330] COX10 transforms heme to heme O - v89:[add_removeInput, add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9864334] Update Tracker - [Reaction:2995330] COX10 transforms heme to heme O - v88:[addLiteratureReference, modifyText] [UpdateTracker:9911033] Update Tracker - [Reaction:2995330] COX10 transforms heme to heme O - v89:[add_removeInput, add_removeOutput]
(hasEvent)	[Pathway:R-HSA-189451] Heme biosynthesis
(precedingEvent)	[Reaction:R-HSA-2995334] COX15 transforms heme O to heme A

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