Reactome | cytosolic FGFR1 fusion mutant dimers [cytosol]

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cytosolic FGFR1 fusion mutant dimers [cytosol] Show undefined attributes

catalystActivities	[CatalystActivity:1839066] protein tyrosine kinase activity of cytosolic FGFR1 fusion mutant dimers [cytosol]
compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-1839036] FGFR1 fusion mutant dimers:TKIs [cytosol] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-1839039] Tyrosine kinase inhibitors bind and inhibit cytosolic FGFR1 fusion dimer phosphorylation - Homo sapiens [Reaction:R-HSA-1839065] Phosphorylation of cytosolic FGFR1 fusion dimers - Homo sapiens
created	[InstanceEdit:1839027] Rothfels, K, 2011-10-27
crossReference	[DatabaseIdentifier:12020830] Mondo:0002582
dbId	1839026
disease	[Disease:1604519] subacute leukemia [Disease:1247687] chronic myeloid leukemia [Disease:1614677] myelodysplastic myeloproliferative cancer [Disease:2317476] acute lymphocytic leukemia
displayName	cytosolic FGFR1 fusion mutant dimers [cytosol]
hasCandidate	[Complex:R-HSA-1637878] CPSF6-FGFR1 fusion mutant dimer [cytosol] - Homo sapiens [Complex:R-HSA-1604541] LRRFIP1-FGFR1 fusion mutant dimer [cytosol] - Homo sapiens [Complex:R-HSA-1637934] MYO18A-FGFR1 fusion mutant dimer [cytosol] - Homo sapiens
hasMember	[Complex:R-HSA-1604545] ZMYM2-FGFR1 fusion mutant dimer [cytosol] - Homo sapiens [Complex:R-HSA-1604535] FGFR1OP-FGFR1 fusion mutant dimer [cytosol] - Homo sapiens [Complex:R-HSA-1604531] CNTRL-FGFR1 fusion mutant dimer [cytosol] - Homo sapiens [Complex:R-HSA-1604525] BCR-FGFR1 fusion mutant dimer [cytosol] - Homo sapiens [Complex:R-HSA-1637884] FGFR1OP2-FGFR1 fusion mutant dimer [cytosol] - Homo sapiens [Complex:R-HSA-1638017] TRIM24-FGFR1 fusion mutant dimer [cytosol] - Homo sapiens [Complex:R-HSA-1637880] CUX1-FGFR1 fusion mutant dimer [cytosol] - Homo sapiens
inDisease	true
maxDepth	3
modified	[InstanceEdit:9832769] Orlic-Milacic, Marija, 2023-04-07
name	cytosolic FGFR1 fusion mutant dimers
producedByEvent	[Reaction:R-HSA-1839031] Dimerization of cytosolic FGFR1 fusion proteins - Homo sapiens
schemaClass	CandidateSet
species	[Species:48887] Homo sapiens
stId	R-HSA-1839026
updateTrackers	[UpdateTracker:9893537] Update Tracker - [CandidateSet:1839026] cytosolic FGFR1 fusion mutant dimers [cytosol] - v56:[modifyName] [UpdateTracker:9905303] Update Tracker - [CandidateSet:1839026] cytosolic FGFR1 fusion mutant dimers [cytosol] - v85:[add_removeDisease, updateContainedMemberOrCandidate]

Referrals

(updatedInstance)	[UpdateTracker:9893537] Update Tracker - [CandidateSet:1839026] cytosolic FGFR1 fusion mutant dimers [cytosol] - v56:[modifyName] [UpdateTracker:9905303] Update Tracker - [CandidateSet:1839026] cytosolic FGFR1 fusion mutant dimers [cytosol] - v85:[add_removeDisease, updateContainedMemberOrCandidate]
(hasComponent)	[Complex:R-HSA-1839036] FGFR1 fusion mutant dimers:TKIs [cytosol]
(input)	[Reaction:R-HSA-1839039] Tyrosine kinase inhibitors bind and inhibit cytosolic FGFR1 fusion dimer phosphorylation [Reaction:R-HSA-1839065] Phosphorylation of cytosolic FGFR1 fusion dimers
(output)	[Reaction:R-HSA-1839031] Dimerization of cytosolic FGFR1 fusion proteins
(diseaseEntity)	[EntityFunctionalStatus:5654536] gain_of_function of cytosolic FGFR1 fusion mutant dimers [cytosol]
(physicalEntity)	[CatalystActivity:1839066] protein tyrosine kinase activity of cytosolic FGFR1 fusion mutant dimers [cytosol]

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