Reactome | Activated FGFR1 mutants and fusions bind PLCG1

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Activated FGFR1 mutants and fusions bind PLCG1 Show undefined attributes

authored	[InstanceEdit:2105031] Rothfels, K, 2012-02-09
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:1839093] Rothfels, K, 2011-10-27
dbId	1839094
disease	[Disease:1500689] cancer
displayName	Activated FGFR1 mutants and fusions bind PLCG1
edited	[InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus	[EntityFunctionalStatus:5654508] gain_of_function of Activated FGFR1 mutants and fusions [plasma membrane]
eventOf	[Pathway:R-HSA-5655302] Signaling by FGFR1 in disease - Homo sapiens
followingEvent	[Reaction:R-HSA-1839098] Activated FGFR1 mutants and fusions phosphorylate PLCG1 - Homo sapiens
input	[DefinedSet:R-HSA-5691527] Activated FGFR1 mutants and fusions [plasma membrane] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-167682] PLCG1 [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:1295608] Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4 [LiteratureReference:2077411] FGFR3 as a therapeutic target of the small molecule inhibitor PKC412 in hematopoietic malignancies [LiteratureReference:2029811] Involvement of fibroblast growth factor receptor 2 isoform switching in mammary oncogenesis [LiteratureReference:2060759] Mutant fibroblast growth factor receptor 3 induces intracellular signaling and cellular transformation in a cell type- and mutation-specific manner [LiteratureReference:2033242] Loss-of-function fibroblast growth factor receptor-2 mutations in melanoma [LiteratureReference:191028] Tyrosine 766 in the fibroblast growth factor receptor-1 is required for FGF-stimulation of phospholipase C, phospholipase D, phospholipase A(2), phosphoinositide 3-kinase and cytoskeletal reorganisation in porcine aortic endothelial cells [LiteratureReference:190978] Intracellular retention, degradation, and signaling of glycosylation-deficient FGFR2 and craniosynostosis syndrome-associated FGFR2C278F [LiteratureReference:1604429] Distinct stem cell myeloproliferative/T lymphoma syndromes induced by ZNF198-FGFR1 and BCR-FGFR1 fusion genes from 8p11 translocations [LiteratureReference:1637873] Activity of TKI258 against primary cells and cell lines with FGFR1 fusion genes associated with the 8p11 myeloproliferative syndrome [LiteratureReference:1679950] Myeloproliferative disorder FOP-FGFR1 fusion kinase recruits phosphoinositide-3 kinase and phospholipase Cgamma at the centrosome [LiteratureReference:1679958] 8p12 stem cell myeloproliferative disorder: the FOP-fibroblast growth factor receptor 1 fusion protein of the t(6;8) translocation induces cell survival mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt/mTOR pathways
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated FGFR1 mutants and fusions bind PLCG1
output	[Complex:R-HSA-1839061] Activated FGFR1 mutants and fusions:PLCG1 [cytosol]
precedingEvent	[Reaction:R-HSA-1839065] Phosphorylation of cytosolic FGFR1 fusion dimers - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2248845] Ezzat, S, 2012-05-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1839094
summation	[Summation:1839073] Although it has not been rigourously established, there is s...

Referrals

(hasEvent)	[Pathway:R-HSA-5655302] Signaling by FGFR1 in disease
(precedingEvent)	[Reaction:R-HSA-1839098] Activated FGFR1 mutants and fusions phosphorylate PLCG1

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