Reactome | Negative regulation by 'viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP:NLRC5 [cytosol]'

Schema > NegativeRegulation > Entries

activeUnit	[EntityWithAccessionedSequence:R-HSA-937324] NLRC5 [cytosol] - Homo sapiens
created	[InstanceEdit:992761] Garapati, P V, 2010-11-04
dbId	992762
displayName	Negative regulation by 'viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP:NLRC5 [cytosol]'
modified	[InstanceEdit:9733355] Wu, Guanming, 2021-06-04
regulatedEntity	[Reaction:R-HSA-168909] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS - Homo sapiens
regulator	[Complex:R-HSA-937325] viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP:NLRC5 [cytosol]
schemaClass	NegativeRegulation
stId	R-HSA-992762

(regulatedBy)	[Reaction:R-HSA-168909] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS
(regulation)	[RegulationReference:9765927] Negative regulation by 'viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP:NLRC5 [cytosol]' SARS-CoV-2 N Protein Targets TRIM25-Mediated RIG-I Activation to Suppress Innate Immunity

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