Reactome | Activated MDA5 binds IPS-1

Schema > Reaction > Entries

Activated MDA5 binds IPS-1 Show undefined attributes

authored	[InstanceEdit:1168652] Shamovsky, V, 2011-01-04
category	binding
compartment	[Compartment:70101] cytosol [Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:1227707] Shamovsky, V, 2011-03-10
dbId	1227709
displayName	Activated MDA5 binds IPS-1
edited	[InstanceEdit:1280191] Shamovsky, V, 2011-05-11
eventOf	[Pathway:R-GGA-1227887] RLR (RIG-like receptor) mediated induction of IFN alpha/beta - Gallus gallus
followingEvent	[Reaction:R-GGA-1227732] IPS1 interacts with TRADD, RIP1 and FADD - Gallus gallus [Reaction:R-GGA-1227891] TRAF3/or TRAF6 interacts with IPS-1 - Gallus gallus [Reaction:R-GGA-1227775] TRAF6/or TRAF2 interacts with IPS-1 - Gallus gallus
inferredFrom	[Reaction:R-HSA-168909] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS - Homo sapiens
input	2 × [EntityWithAccessionedSequence:R-GGA-1227704] IPS-1 [mitochondrial outer membrane] [Complex:R-GGA-1227681] viral dsRNA:MDA5 [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:177847] IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction [LiteratureReference:918219] Crystal structure of human IPS-1/MAVS/VISA/Cardif caspase activation recruitment domain [LiteratureReference:918176] VISA is an adapter protein required for virus-triggered IFN-beta signaling
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated MDA5 binds IPS-1
output	[Complex:R-GGA-1227703] dsRNA:MDA5:IPS1 [mitochondrial outer membrane]
precedingEvent	[Reaction:R-GGA-1227694] dsRNA binds to MDA5 - Gallus gallus
regulatedBy	[NegativeRegulation:R-GGA-1227685] Negative regulation by 'IPS1: NLRX1 [mitochondrial outer membrane]' [NegativeRegulation:R-GGA-1227691] Negative regulation by 'viral dsRNA:MDA5:NLRC5 [cytosol]'
regulationReference	[RegulationReference:9643037] Negative regulation by 'IPS1: NLRX1 [mitochondrial outer membrane]' NLRX1 is a regulator of mitochondrial antiviral immunity
relatedSpecies	[Species:9014381] Infectious bronchitis virus
releaseDate	2011-06-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1295492] Garapati, P V, 2011-05-16
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-1227709
summation	[Summation:1237383] Predicted chicken interferon beta promoter stimulator 1(IPS...
updateTrackers	[UpdateTracker:9786013] Update Tracker - [Reaction:1227709] Activated MDA5 binds IPS-1 - v50:[add_removeRegulator]

Referrals

(updatedInstance)	[UpdateTracker:9786013] Update Tracker - [Reaction:1227709] Activated MDA5 binds IPS-1 - v50:[add_removeRegulator]
(hasEvent)	[Pathway:R-GGA-1227887] RLR (RIG-like receptor) mediated induction of IFN alpha/beta
(precedingEvent)	[Reaction:R-GGA-1227732] IPS1 interacts with TRADD, RIP1 and FADD [Reaction:R-GGA-1227891] TRAF3/or TRAF6 interacts with IPS-1 [Reaction:R-GGA-1227775] TRAF6/or TRAF2 interacts with IPS-1
(inferredTo)	[Reaction:R-HSA-168909] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS