Reactome | Activation of the AP-1 family of transcription factors

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Activation of the AP-1 family of transcription factors Show undefined attributes

authored	[InstanceEdit:450323] Shamovsky, V, 2009-12-16
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:450323] Shamovsky, V, 2009-12-16
crossReference	[DatabaseIdentifier:12819513] BioModels Database:BIOMD0000000251 [DatabaseIdentifier:12819447] BioModels Database:BIOMD0000000504 [DatabaseIdentifier:12819451] BioModels Database:BIOMD0000000477
dbId	450341
displayName	Activation of the AP-1 family of transcription factors
edited	[InstanceEdit:532463] Shamovsky, V, 2010-02-27
eventOf	[Pathway:R-HSA-450282] MAPK targets/ Nuclear events mediated by MAP kinases - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-168053] Phosphorylated MAPKs phosphorylate ATF-2 - Homo sapiens [Reaction:R-HSA-168136] Activated JNKs phosphorylate c-JUN - Homo sapiens [Reaction:R-HSA-450325] c-FOS activation by phospho ERK1/2 - Homo sapiens [Reaction:R-HSA-168440] Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer. - Homo sapiens [Reaction:R-HSA-450292] Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer. - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2016-12-21
literatureReference	[LiteratureReference:500499] AP-1 function and regulation [LiteratureReference:500501] The regulation of AP-1 activity by mitogen-activated protein kinases [LiteratureReference:500505] AP-1 subunits: quarrel and harmony among siblings
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	Activation of the AP-1 family of transcription factors
orthologousEvent	[Pathway:R-SCE-450341] Activation of the AP-1 family of transcription factors - Saccharomyces cerevisiae [Pathway:R-SPO-450341] Activation of the AP-1 family of transcription factors - Schizosaccharomyces pombe [Pathway:R-CEL-450341] Activation of the AP-1 family of transcription factors - Caenorhabditis elegans [Pathway:R-DME-450341] Activation of the AP-1 family of transcription factors - Drosophila melanogaster [Pathway:R-GGA-450341] Activation of the AP-1 family of transcription factors - Gallus gallus [Pathway:R-XTR-450341] Activation of the AP-1 family of transcription factors - Xenopus tropicalis [Pathway:R-DRE-450341] Activation of the AP-1 family of transcription factors - Danio rerio [Pathway:R-SSC-450341] Activation of the AP-1 family of transcription factors - Sus scrofa [Pathway:R-BTA-450341] Activation of the AP-1 family of transcription factors - Bos taurus [Pathway:R-CFA-450341] Activation of the AP-1 family of transcription factors - Canis familiaris [Pathway:R-RNO-450341] Activation of the AP-1 family of transcription factors - Rattus norvegicus [Pathway:R-MMU-450341] Activation of the AP-1 family of transcription factors - Mus musculus
releaseDate	2010-03-16
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:532466] Gillespie, ME, 2010-02-27
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-450341
summation	[Summation:500504] Activator protein-1 (AP-1) is a collective term referring to...
updateTrackers	[UpdateTracker:9789745] Update Tracker - [Pathway:450341] Activation of the AP-1 family of transcription factors - v37:[updateContainedRLE] [UpdateTracker:9782085] Update Tracker - [Pathway:450341] Activation of the AP-1 family of transcription factors - v59:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9789745] Update Tracker - [Pathway:450341] Activation of the AP-1 family of transcription factors - v37:[updateContainedRLE] [UpdateTracker:9782085] Update Tracker - [Pathway:450341] Activation of the AP-1 family of transcription factors - v59:[updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-450282] MAPK targets/ Nuclear events mediated by MAP kinases

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