Reactome | Activation and dimerization of c-JUN in the nucleus

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Activation and dimerization of c-JUN in the nucleus Show undefined attributes

authored	[InstanceEdit:438031] Shamovsky, V, 2009-09-22
catalystActivity	[CatalystActivity:438001] JUN kinase activity of phosphorylated JNK homologs [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:438021] Shamovsky, V, 2009-09-22
dbId	438026
displayName	Activation and dimerization of c-JUN in the nucleus
edited	[InstanceEdit:668815] Shamovsky, V, 2010-05-04
eventOf	[Pathway:R-GGA-437986] Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation - Gallus gallus
inferredFrom	[Reaction:R-HSA-168136] Activated JNKs phosphorylate c-JUN - Homo sapiens
input	4 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] 2 × [EntityWithAccessionedSequence:R-GGA-438016] c-JUN [nucleoplasm]
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:437979] c-Jun expression, activation and function in neural cell death, inflammation and repair
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activation and dimerization of c-JUN in the nucleus
output	[Complex:R-GGA-437991] activated c-JUN dimer [nucleoplasm] 4 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm]
precedingEvent	[Reaction:R-GGA-437995] Activated JNK migrates to the nucleoplasm - Gallus gallus
regulatedBy	[NegativeRegulation:R-GGA-442857] Negative regulation by 'MAPK phosphatases [nucleoplasm]'
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:789693] D'Eustachio, P, 2010-05-23
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-438026
summation	[Summation:446230] Shortly after phosphorylation JNKs are translocated to nucl...

Referrals

(hasEvent)	[Pathway:R-GGA-437986] Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation
(inferredTo)	[Reaction:R-HSA-168136] Activated JNKs phosphorylate c-JUN

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