Reactome | Minus-strand DNA synthesis

Schema > Pathway > Entries

Minus-strand DNA synthesis Show undefined attributes

authored	[InstanceEdit:180401] Gopinathrao, G, D'Eustachio, P, 2006-05-18 20:10:22
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:164501] D'Eustachio, P, 2005-05-24 15:07:45
crossReference	[DatabaseIdentifier:12020765] Mondo:0005109
dbId	164516
disease	[Disease:1660559] Human immunodeficiency virus infectious disease
displayName	Minus-strand DNA synthesis
edited	[InstanceEdit:180401] Gopinathrao, G, D'Eustachio, P, 2006-05-18 20:10:22
eventOf	[Pathway:R-HSA-162589] Reverse Transcription of HIV RNA - Homo sapiens
figure	[Figure:180424] /figures/RT_minus.jpg
goBiologicalProcess	[GO_BiologicalProcess:17126] RNA-templated DNA biosynthetic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-164504] Synthesis of minus strand strong stop DNA (-sssDNA) - Homo sapiens [Reaction:R-HSA-9697051] RTC binds NRTIs - Homo sapiens [Reaction:R-HSA-164519] RNase H-mediated cleavage of the RNA strand of the -sssDNA:RNA duplex - Homo sapiens [Reaction:R-HSA-182859] RNase H-mediated degradation of the RNA strand of the -sssDNA:RNA duplex - Homo sapiens [Reaction:R-HSA-164503] First strand transfer mediated by Repeated (R) sequence - Homo sapiens [Reaction:R-HSA-164520] Minus strand DNA synthesis resumes - Homo sapiens [Reaction:R-HSA-164528] RNase H-mediated cleavage of the template strand - Homo sapiens [Reaction:R-HSA-182795] RNase H-mediated degradation of the template strand - Homo sapiens
isInDisease	true
isInferred	false
lastUpdatedDate	2020-09-24
literatureReference	[Book:175762] 9780879695712 Reverse Transcriptase and the Generation of Retroviral DNA Retroviruses Coffin, JM [LiteratureReference:175772] The reverse transcriptase of HIV-1: from enzymology to therapeutic intervention [LiteratureReference:175750] Interaction of tRNALys with the p66/p66 form of HIV-1 reverse transcriptase stimulates DNA polymerase and ribonuclease H activities [LiteratureReference:175768] Retroviral reverse transcription and integration: progress and problems [LiteratureReference:175646] The HIV-1 reverse transcription (RT) process as target for RT inhibitors
maxDepth	2
modified	[InstanceEdit:9847082] Weiser, Joel, 2023-10-12
name	Minus-strand DNA synthesis minus-strand DNA synthesis
relatedSpecies	[Species:164493] Human immunodeficiency virus 1
releaseDate	2006-11-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:188936] Hughes, SH, 2006-10-30 22:00:51
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-164516
summation	[Summation:177464] In the first part of reverse transcription, minus-strand syn...
updateTrackers	[UpdateTracker:9776802] Update Tracker - [Pathway:164516] Minus-strand DNA synthesis - v74:[addHasEvent, updateContainedRLE] [UpdateTracker:9783165] Update Tracker - [Pathway:164516] Minus-strand DNA synthesis - v57:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9776802] Update Tracker - [Pathway:164516] Minus-strand DNA synthesis - v74:[addHasEvent, updateContainedRLE] [UpdateTracker:9783165] Update Tracker - [Pathway:164516] Minus-strand DNA synthesis - v57:[updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-162589] Reverse Transcription of HIV RNA