Reactome | Synthesis of minus strand strong stop DNA (-sssDNA)

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Synthesis of minus strand strong stop DNA (-sssDNA) Show undefined attributes

authored	[InstanceEdit:180401] Gopinathrao, G, D'Eustachio, P, 2006-05-18 20:10:22
catalystActivity	[CatalystActivity:173806] RNA-directed DNA polymerase activity of RTC with tRNA primer:RNA template [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:164501] D'Eustachio, P, 2005-05-24 15:07:45
crossReference	[DatabaseIdentifier:12020765] Mondo:0005109
dbId	164504
disease	[Disease:1660559] Human immunodeficiency virus infectious disease
displayName	Synthesis of minus strand strong stop DNA (-sssDNA)
edited	[InstanceEdit:180401] Gopinathrao, G, D'Eustachio, P, 2006-05-18 20:10:22
eventOf	[Pathway:R-HSA-164516] Minus-strand DNA synthesis - Homo sapiens
figure	[Figure:180453] /figures/RT_event1.jpg
followingEvent	[Reaction:R-HSA-164519] RNase H-mediated cleavage of the RNA strand of the -sssDNA:RNA duplex - Homo sapiens
input	[SimpleEntity:R-ALL-8866361] dNTP [cytosol] [Complex:R-HSA-173801] RTC with tRNA primer:RNA template [cytosol]
isInDisease	true
isInferred	false
literatureReference	[Book:175762] 9780879695712 Reverse Transcriptase and the Generation of Retroviral DNA Retroviruses Coffin, JM [LiteratureReference:175646] The HIV-1 reverse transcription (RT) process as target for RT inhibitors
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Synthesis of minus strand strong stop DNA (-sssDNA)
output	[SimpleEntity:R-ALL-111294] PPi [cytosol] [Complex:R-HSA-173774] RTC with minus sssDNA:tRNA primer:RNA template [cytosol]
precedingEvent	[Reaction:R-HSA-164527] Annealing of 3'-end of unwound transfer RNA primer with genomic RNA - Homo sapiens
regulatedBy	[NegativeRegulation:9690701] Negative regulation by 'carbovir triphosphate [cytosol]' [NegativeRegulation:9693559] Negative regulation by 'RTC:NRTIs [cytosol]'
regulationReference	[RegulationReference:9690703] Negative regulation by 'carbovir triphosphate [cytosol]' A review of the pharmacokinetics of abacavir
relatedSpecies	[Species:164493] Human immunodeficiency virus 1
releaseDate	2006-11-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:188936] Hughes, SH, 2006-10-30 22:00:51
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-164504
summation	[Summation:177469] To catalyze DNA synthesis, retroviral reverse transcriptase ...
updateTrackers	[UpdateTracker:9776753] Update Tracker - [Reaction:164504] Synthesis of minus strand strong stop DNA (-sssDNA) - v74:[addRegulator] [UpdateTracker:9783140] Update Tracker - [Reaction:164504] Synthesis of minus strand strong stop DNA (-sssDNA) - v57:[add_removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9776753] Update Tracker - [Reaction:164504] Synthesis of minus strand strong stop DNA (-sssDNA) - v74:[addRegulator] [UpdateTracker:9783140] Update Tracker - [Reaction:164504] Synthesis of minus strand strong stop DNA (-sssDNA) - v57:[add_removeInput]
(hasEvent)	[Pathway:R-HSA-164516] Minus-strand DNA synthesis
(precedingEvent)	[Reaction:R-HSA-164519] RNase H-mediated cleavage of the RNA strand of the -sssDNA:RNA duplex