Reactome | RNase H-mediated cleavage of the template strand

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RNase H-mediated cleavage of the template strand Show undefined attributes

authored	[InstanceEdit:180401] Gopinathrao, G, D'Eustachio, P, 2006-05-18 20:10:22
catalystActivity	[CatalystActivity:173770] RNA-DNA hybrid ribonuclease activity of RTC with minus strand DNA synthesis initiated from 3'-end [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:164501] D'Eustachio, P, 2005-05-24 15:07:45
crossReference	[DatabaseIdentifier:12020765] Mondo:0005109
dbId	164528
disease	[Disease:1660559] Human immunodeficiency virus infectious disease
displayName	RNase H-mediated cleavage of the template strand
edited	[InstanceEdit:180401] Gopinathrao, G, D'Eustachio, P, 2006-05-18 20:10:22
eventOf	[Pathway:R-HSA-164516] Minus-strand DNA synthesis - Homo sapiens
figure	[Figure:180422] /figures/RT_event4.jpg
followingEvent	[Reaction:R-HSA-182795] RNase H-mediated degradation of the template strand - Homo sapiens
input	[Complex:R-HSA-173786] RTC with minus strand DNA synthesis initiated from 3'-end [cytosol]
isInDisease	true
isInferred	false
literatureReference	[Book:175762] 9780879695712 Reverse Transcriptase and the Generation of Retroviral DNA Retroviruses Coffin, JM [LiteratureReference:177421] Effects of mutations in the G tract of the human immunodeficiency virus type 1 polypurine tract on virus replication and RNase H cleavage [LiteratureReference:177435] The sequence features important for plus strand priming by human immunodeficiency virus type 1 reverse transcriptase [LiteratureReference:175646] The HIV-1 reverse transcription (RT) process as target for RT inhibitors
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RNase H-mediated cleavage of the template strand
output	[Complex:R-HSA-173789] RTC with extensive RNase-H digestion [cytosol]
precedingEvent	[Reaction:R-HSA-164520] Minus strand DNA synthesis resumes - Homo sapiens
relatedSpecies	[Species:164493] Human immunodeficiency virus 1
releaseDate	2006-11-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:188936] Hughes, SH, 2006-10-30 22:00:51
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-164528
summation	[Summation:182827] As the reverse transcriptase activity of the HIV-1 RT hetero...

Referrals

(hasEvent)	[Pathway:R-HSA-164516] Minus-strand DNA synthesis
(precedingEvent)	[Reaction:R-HSA-182795] RNase H-mediated degradation of the template strand

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