Reactome | RNase H-mediated degradation of the RNA strand of the -sssDNA:RNA duplex

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RNase H-mediated degradation of the RNA strand of the -sssDNA:RNA duplex Show undefined attributes

authored	[InstanceEdit:180401] Gopinathrao, G, D'Eustachio, P, 2006-05-18 20:10:22
catalystActivity	[CatalystActivity:182837] RNA-DNA hybrid ribonuclease activity of RT [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:182820] Gopinathrao, G, 2006-07-19 16:21:19
crossReference	[DatabaseIdentifier:12020765] Mondo:0005109
dbId	182859
disease	[Disease:1660559] Human immunodeficiency virus infectious disease
displayName	RNase H-mediated degradation of the RNA strand of the -sssDNA:RNA duplex
eventOf	[Pathway:R-HSA-164516] Minus-strand DNA synthesis - Homo sapiens
figure	[Figure:180423] /figures/RT_event2.jpg
followingEvent	[Reaction:R-HSA-164503] First strand transfer mediated by Repeated (R) sequence - Homo sapiens
input	[Complex:R-HSA-182804] RTC with nicked minus sssDNA:tRNA primer:RNA template [cytosol]
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:182833] Mechanism and fidelity of HIV reverse transcriptase [LiteratureReference:182868] The sequential mechanism of HIV reverse transcriptase RNase H [LiteratureReference:182873] Unique progressive cleavage mechanism of HIV reverse transcriptase RNase H
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RNase H-mediated degradation of the RNA strand of the -sssDNA:RNA duplex
output	[Complex:R-HSA-173773] RTC with degraded RNA template and minus sssDNA [cytosol]
precedingEvent	[Reaction:R-HSA-164519] RNase H-mediated cleavage of the RNA strand of the -sssDNA:RNA duplex - Homo sapiens
relatedSpecies	[Species:164493] Human immunodeficiency virus 1
releaseDate	2006-11-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:188936] Hughes, SH, 2006-10-30 22:00:51
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-182859
summation	[Summation:182818] The rate of RNase H cleavage is substantially lower than the...

Referrals

(hasEvent)	[Pathway:R-HSA-164516] Minus-strand DNA synthesis
(precedingEvent)	[Reaction:R-HSA-164503] First strand transfer mediated by Repeated (R) sequence

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