Reactome | RTC binds NRTIs

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RTC binds NRTIs Show undefined attributes

authored	[InstanceEdit:9680828] Jassal, Bijay, 2020-03-30
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9697052] Jassal, Bijay, 2020-08-05
crossReference	[DatabaseIdentifier:12020765] Mondo:0005109
dbId	9697051
definition	Inhibition
deleted	[Deleted:9697055] Deletion of instance: 9680851
disease	[Disease:1660559] Human immunodeficiency virus infectious disease
displayName	RTC binds NRTIs
edited	[InstanceEdit:9680828] Jassal, Bijay, 2020-03-30
eventOf	[Pathway:R-HSA-164516] Minus-strand DNA synthesis - Homo sapiens
input	[DefinedSet:R-ALL-9681061] NRTIs [cytosol] [Complex:R-HSA-173801] RTC with tRNA primer:RNA template [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9684434] Emtricitabine [LiteratureReference:9684415] The triple combination of tenofovir, emtricitabine and efavirenz shows synergistic anti-HIV-1 activity in vitro: a mechanism of action study [LiteratureReference:9681074] Efficacy of Tenofovir 1% Vaginal Gel in Reducing the Risk of HIV-1 and HSV-2 Infection [LiteratureReference:9681029] Tenofovir alafenamide: A novel prodrug of tenofovir for the treatment of Human Immunodeficiency Virus
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RTC binds NRTIs
output	[Complex:R-HSA-9680894] RTC:NRTIs [cytosol]
relatedSpecies	[Species:164493] Human immunodeficiency virus 1
releaseDate	2020-09-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9688552] Shoichet, Brian, 2020-05-14
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9697051
summation	[Summation:9680926] Antiretroviral (ARV) therapy, comprising a backbone of two n...

Referrals

(replacementInstances)	[Deleted:9697055] Deletion of instance: 9680851
(hasEvent)	[Pathway:R-HSA-164516] Minus-strand DNA synthesis

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