Reactome | Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13

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Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 Show undefined attributes

authored	[InstanceEdit:1442471] Jupe, S, 2011-07-12
catalystActivity	[CatalystActivity:2537494] metalloendopeptidase activity of MMP1-3, 7-9, 12, 13 [extracellular region]
category	omitted
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:1454796] Jupe, S, 2011-07-18
dbId	1454757
displayName	Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13
edited	[InstanceEdit:2580335] Jupe, S, 2012-11-12
eventOf	[Pathway:R-HSA-1442490] Collagen degradation - Homo sapiens
input	[DefinedSet:R-HSA-2537527] Cleaved collagen fibrils [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2537480] H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen [LiteratureReference:1602465] SV40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages [LiteratureReference:2537496] Calprotectin inhibits matrix metalloproteinases by sequestration of zinc [LiteratureReference:2537473] Role of zinc-binding- and hemopexin domain-encoded sequences in the substrate specificity of collagenase and stromelysin-2 as revealed by chimeric proteins [LiteratureReference:1564149] Macrophage metalloelastase degrades matrix and myelin proteins and processes a tumour necrosis factor-alpha fusion protein [LiteratureReference:2537508] Expression of three membrane-type matrix metalloproteinases (MT-MMPs) in rat vascular smooth muscle cells and characterization of MT3-MMPs with and without transmembrane domain [LiteratureReference:2537525] Catalytic activities and substrate specificity of the human membrane type 4 matrix metalloproteinase catalytic domain [LiteratureReference:2537513] Purification of a gelatin-degrading type IV collagenase secreted by ras oncogene-transformed fibroblasts [LiteratureReference:2537521] Biochemical characterization of the catalytic domain of human matrix metalloproteinase 19. Evidence for a role as a potent basement membrane degrading enzyme [LiteratureReference:2537509] Cloning and characterization of a novel matrix metalloproteinase (MMP), CMMP, from chicken embryo fibroblasts. CMMP, Xenopus XMMP, and human MMP19 have a conserved unique cysteine in the catalytic domain
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13
orthologousEvent	[BlackBoxEvent:R-MMU-1454757] Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 - Mus musculus [BlackBoxEvent:R-RNO-1454757] Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 - Rattus norvegicus [BlackBoxEvent:R-CFA-1454757] Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 - Canis familiaris [BlackBoxEvent:R-BTA-1454757] Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 - Bos taurus [BlackBoxEvent:R-SSC-1454757] Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 - Sus scrofa [BlackBoxEvent:R-DRE-1454757] Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 - Danio rerio [BlackBoxEvent:R-XTR-1454757] Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 - Xenopus tropicalis [BlackBoxEvent:R-GGA-1454757] Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 - Gallus gallus [BlackBoxEvent:R-DME-1454757] Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 - Drosophila melanogaster [BlackBoxEvent:R-CEL-1454757] Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 - Caenorhabditis elegans
precedingEvent	[Reaction:R-HSA-1454822] Collagen type I degradation by MMP1,2,8,13, PRSS2 - Homo sapiens [Reaction:R-HSA-1458433] Collagen type I degradation by MMP14 - Homo sapiens [Reaction:R-HSA-2473596] Collagen type I degradation by MMP15 - Homo sapiens [Reaction:R-HSA-1474197] Collagen type II degradation by MMP1,3,8,13,PRSS2 - Homo sapiens [Reaction:R-HSA-1474196] Collagen type II degradation by MMP14 - Homo sapiens [Reaction:R-HSA-1474213] Collagen type III degradation by MMP1,8,9,13 - Homo sapiens [Reaction:R-HSA-2485111] Collagen type III degradation by MMP10 - Homo sapiens [Reaction:R-HSA-1474210] Collagen type III degradation by MMP14 - Homo sapiens [Reaction:R-HSA-1564142] Collagen type IV degradation by MMP2,3,4,9,10,12 - Homo sapiens [Reaction:R-HSA-1564164] Collagen type V degradation by MMP2,9,10 - Homo sapiens [Reaction:R-HSA-1564112] Collagen type VI degradation by MMP2,9,11 - Homo sapiens [Reaction:R-HSA-1564120] Collagen type VII degradation by MMP1,2,3 - Homo sapiens [Reaction:R-HSA-2482180] Collagen type VIII degradation by ELANE - Homo sapiens [Reaction:R-HSA-1564169] Collagen type VIII degradation by MMP1 - Homo sapiens [Reaction:R-HSA-1564184] Collagen type IX degradation by MMP3,13 - Homo sapiens [Reaction:R-HSA-1564143] Collagen type X degradation by MMP1,2 - Homo sapiens [Reaction:R-HSA-2484882] Collagen type X degradation by MMP3, 13 - Homo sapiens [Reaction:R-HSA-1564179] Collagen type XI degradation by MMP1,2,3,9 - Homo sapiens [Reaction:R-HSA-2168046] Collagen type XII degradation by MMP12 - Homo sapiens [Reaction:R-HSA-1564117] Collagen type XIV degradation by MMP9,13 - Homo sapiens [Reaction:R-HSA-2168982] Collagen type XVI degradation by MMP9 - Homo sapiens [BlackBoxEvent:R-HSA-2473594] Collagen type II degradation by MMP15 - Homo sapiens [BlackBoxEvent:R-HSA-2473584] Collagen type III degradation by MMP15 - Homo sapiens
releaseDate	2012-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2514803] Sorsa, Timo, 2012-10-08
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-1454757
summation	[Summation:1454743] Gelatin is formed when collagen becomes partly or completely...

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(hasEvent)

[Pathway:R-HSA-1442490] Collagen degradation

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