Reactome | Collagen type I degradation by MMP15

Schema > Reaction > Entries

authored	[InstanceEdit:1442471] Jupe, S, 2011-07-12
catalystActivity	[CatalystActivity:2473585] metalloendopeptidase activity of MMP15 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:2473595] Jupe, S, 2012-09-24
dbId	2473596
displayName	Collagen type I degradation by MMP15
edited	[InstanceEdit:2580335] Jupe, S, 2012-11-12
eventOf	[Pathway:R-HSA-1442490] Collagen degradation - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-2537499] Gelatin degradation by MMP19 - Homo sapiens [BlackBoxEvent:R-HSA-1454757] Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 - Homo sapiens
input	[Polymer:R-HSA-1474201] Collagen type I fibril [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1458428] TIMP independence of matrix metalloproteinase (MMP)-2 activation by membrane type 2 (MT2)-MMP is determined by contributions of both the MT2-MMP catalytic and hemopexin C domains
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Collagen type I degradation by MMP15
output	[Polymer:R-HSA-2467150] Cleaved collagen type I fibril [extracellular region]
releaseDate	2012-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2514803] Sorsa, Timo, 2012-10-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2473596
summation	[Summation:2473576] The membrane-type MMP MMP15 (MT2-MMP) is a fibrillar collage...

(precedingEvent)	[BlackBoxEvent:R-HSA-2537499] Gelatin degradation by MMP19 [BlackBoxEvent:R-HSA-1454757] Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13
(hasEvent)	[Pathway:R-HSA-1442490] Collagen degradation

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