Reactome | Collagen type I degradation by MMP14

Schema > Reaction > Entries

authored	[InstanceEdit:1442471] Jupe, S, 2011-07-12
catalystActivity	[CatalystActivity:1605824] metalloendopeptidase activity of MMP14,TMPRSS6 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:1458406] Jupe, S, 2011-07-21
dbId	1458433
displayName	Collagen type I degradation by MMP14
edited	[InstanceEdit:2580335] Jupe, S, 2012-11-12
eventOf	[Pathway:R-HSA-1442490] Collagen degradation - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-2537499] Gelatin degradation by MMP19 - Homo sapiens [BlackBoxEvent:R-HSA-1454757] Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 - Homo sapiens
inferredFrom	[Reaction:R-NUL-2473583] Collagen type I degradation by MMP14 - Cavia porcellus
input	[Polymer:R-HSA-1474201] Collagen type I fibril [extracellular region]
isChimeric	false
isInDisease	false
isInferred	true
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Collagen type I degradation by MMP14
output	[Polymer:R-HSA-2467150] Cleaved collagen type I fibril [extracellular region]
releaseDate	2012-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2514803] Sorsa, Timo, 2012-10-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1458433
summation	[Summation:1458420] The membrane-type MMP MMP14 (MT1-MMP) is a fibrillar collage...

(precedingEvent)	[BlackBoxEvent:R-HSA-2537499] Gelatin degradation by MMP19 [BlackBoxEvent:R-HSA-1454757] Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13
(hasEvent)	[Pathway:R-HSA-1442490] Collagen degradation
(inferredTo)	[Reaction:R-NUL-2473583] Collagen type I degradation by MMP14

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