Reactome | Collagen type VI degradation by MMP2,9,11

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Collagen type VI degradation by MMP2,9,11 Show undefined attributes

authored	[InstanceEdit:1442471] Jupe, S, 2011-07-12
catalystActivity	[CatalystActivity:2470200] metalloendopeptidase activity of MMP2,9,11 [extracellular region]
category	transition
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:1564189] Jupe, S, 2011-09-05
dbId	1564112
displayName	Collagen type VI degradation by MMP2,9,11
edited	[InstanceEdit:2580335] Jupe, S, 2012-11-12
eventOf	[Pathway:R-HSA-1442490] Collagen degradation - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-2537499] Gelatin degradation by MMP19 - Homo sapiens [BlackBoxEvent:R-HSA-1454757] Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 - Homo sapiens
input	[Polymer:R-HSA-1637827] Collagen type VI fibril [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2161312] MMP mediated degradation of type VI collagen is highly associated with liver fibrosis--identification and validation of a novel biochemical marker assay [LiteratureReference:1564159] Matrix metalloproteinase-11/stromelysin-3 exhibits collagenolytic function against collagen VI under normal and malignant conditions
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Collagen type VI degradation by MMP2,9,11
orthologousEvent	[Reaction:R-CEL-1564112] Collagen type VI degradation by MMP2,9,11 - Caenorhabditis elegans [Reaction:R-SSC-1564112] Collagen type VI degradation by MMP2,9,11 - Sus scrofa [Reaction:R-BTA-1564112] Collagen type VI degradation by MMP2,9,11 - Bos taurus [Reaction:R-MMU-1564112] Collagen type VI degradation by MMP2,9,11 - Mus musculus
output	[Polymer:R-HSA-2470223] Cleaved collagen type VI fibril [extracellular region]
releaseDate	2012-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2514803] Sorsa, Timo, 2012-10-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1564112
summation	[Summation:1564084] Type VI collagen aggregates into distinctive microfibrils kn...

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-2537499] Gelatin degradation by MMP19 [BlackBoxEvent:R-HSA-1454757] Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13
(hasEvent)	[Pathway:R-HSA-1442490] Collagen degradation

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