Reactome | Collagen type III degradation by MMP1,8,9,13

Schema > Reaction > Entries

Collagen type III degradation by MMP1,8,9,13 Show undefined attributes

authored	[InstanceEdit:1442471] Jupe, S, 2011-07-12
catalystActivity	[CatalystActivity:1606420] metalloendopeptidase activity of MMP1,8,9,13 [extracellular region]
category	transition
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:1474204] Jupe, S, 2011-08-05
dbId	1474213
displayName	Collagen type III degradation by MMP1,8,9,13
edited	[InstanceEdit:2580335] Jupe, S, 2012-11-12
eventOf	[Pathway:R-HSA-1442490] Collagen degradation - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-2537499] Gelatin degradation by MMP19 - Homo sapiens [BlackBoxEvent:R-HSA-1454757] Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 - Homo sapiens
input	[Polymer:R-HSA-1474212] Collagen type III fibril [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1454859] Collagenase unwinds triple-helical collagen prior to peptide bond hydrolysis [LiteratureReference:1458414] The collagen substrate specificity of human skin fibroblast collagenase [LiteratureReference:1458399] The collagen substrate specificity of human neutrophil collagenase [LiteratureReference:1458404] Biochemical characterization of human collagenase-3 [LiteratureReference:1458418] Membrane type 1 matrix metalloproteinase digests interstitial collagens and other extracellular matrix macromolecules
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Collagen type III degradation by MMP1,8,9,13
orthologousEvent	[Reaction:R-GGA-1474213] Collagen type III degradation by MMP1,8,9,13 - Gallus gallus [Reaction:R-XTR-1474213] Collagen type III degradation by MMP1,8,9,13 - Xenopus tropicalis [Reaction:R-DRE-1474213] Collagen type III degradation by MMP1,8,9,13 - Danio rerio [Reaction:R-SSC-1474213] Collagen type III degradation by MMP1,8,9,13 - Sus scrofa [Reaction:R-BTA-1474213] Collagen type III degradation by MMP1,8,9,13 - Bos taurus [Reaction:R-CFA-1474213] Collagen type III degradation by MMP1,8,9,13 - Canis familiaris [Reaction:R-RNO-1474213] Collagen type III degradation by MMP1,8,9,13 - Rattus norvegicus [Reaction:R-MMU-1474213] Collagen type III degradation by MMP1,8,9,13 - Mus musculus
output	[Polymer:R-HSA-2468104] Cleaved collagen type III fibril [extracellular region]
releaseDate	2012-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2514803] Sorsa, Timo, 2012-10-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1474213
summation	[Summation:1454813] MMP1 (Welgus et al. 1981), MMP8 (Hasty et al. 1987), and MMP...

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-2537499] Gelatin degradation by MMP19 [BlackBoxEvent:R-HSA-1454757] Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13
(hasEvent)	[Pathway:R-HSA-1442490] Collagen degradation