Reactome | Collagen type II degradation by MMP15

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Collagen type II degradation by MMP15 Show undefined attributes

authored	[InstanceEdit:1442471] Jupe, S, 2011-07-12
catalystActivity	[CatalystActivity:2473585] metalloendopeptidase activity of MMP15 [plasma membrane]
category	omitted
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:2473595] Jupe, S, 2012-09-24
dbId	2473594
displayName	Collagen type II degradation by MMP15
edited	[InstanceEdit:2580335] Jupe, S, 2012-11-12
eventOf	[Pathway:R-HSA-1442490] Collagen degradation - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-2537499] Gelatin degradation by MMP19 - Homo sapiens [BlackBoxEvent:R-HSA-1454757] Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 - Homo sapiens
input	[Polymer:R-HSA-1474209] Collagen type II fibril [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1458428] TIMP independence of matrix metalloproteinase (MMP)-2 activation by membrane type 2 (MT2)-MMP is determined by contributions of both the MT2-MMP catalytic and hemopexin C domains
maxDepth	1
modified	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
name	Collagen type II degradation by MMP15
orthologousEvent	[BlackBoxEvent:R-DRE-2473594] Collagen type II degradation by MMP15 - Danio rerio [BlackBoxEvent:R-SSC-2473594] Collagen type II degradation by MMP15 - Sus scrofa [BlackBoxEvent:R-BTA-2473594] Collagen type II degradation by MMP15 - Bos taurus [BlackBoxEvent:R-CFA-2473594] Collagen type II degradation by MMP15 - Canis familiaris [BlackBoxEvent:R-RNO-2473594] Collagen type II degradation by MMP15 - Rattus norvegicus [BlackBoxEvent:R-MMU-2473594] Collagen type II degradation by MMP15 - Mus musculus
output	[Polymer:R-HSA-2468059] Cleaved collagen type II fibril [extracellular region]
releaseDate	2012-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2514803] Sorsa, Timo, 2012-10-08
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-2473594
summation	[Summation:2473593] The membrane-type MMP MMP15 (MT2-MMP) is a fibrillar collage...

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-2537499] Gelatin degradation by MMP19 [BlackBoxEvent:R-HSA-1454757] Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13
(hasEvent)	[Pathway:R-HSA-1442490] Collagen degradation

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