Reactome | Interaction of E3 ligase with ISG15:E2 complex

Schema > Reaction > Entries

Interaction of E3 ligase with ISG15:E2 complex Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10028647
displayName	Interaction of E3 ligase with ISG15:E2 complex
eventOf	[Pathway:R-MMU-1169408] ISG15 antiviral mechanism - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-1169406] ISGylation of host proteins - Mus musculus [Reaction:R-MMU-1169405] ISGylation of protein phosphatase 1 beta (PP2CB) - Mus musculus [Reaction:R-MMU-1169402] ISGylation of E2 conjugating enzymes - Mus musculus [Reaction:R-MMU-1169398] ISGylation of host protein filamin B - Mus musculus [BlackBoxEvent:R-MMU-9833973] ISGylation of PKR - Mus musculus [Reaction:R-MMU-1169394] ISGylation of IRF3 - Mus musculus
inferredFrom	[Reaction:R-HSA-1169403] Interaction of E3 ligase with ISG15:E2 complex - Homo sapiens
input	[CandidateSet:R-MMU-1169381] ISG15 E3 ligases [cytosol] [Complex:R-MMU-1169385] ISG15:UBCH8 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Interaction of E3 ligase with ISG15:E2 complex
output	[Complex:R-MMU-1169383] ISG15:UBCH8:ISG15 E3 ligase [cytosol]
precedingEvent	[Reaction:R-MMU-1169404] Transfer of ISG15 from E1 to E2 (UBCH8) - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-1169403
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-1169408] ISG15 antiviral mechanism
(precedingEvent)	[Reaction:R-MMU-1169406] ISGylation of host proteins [Reaction:R-MMU-1169405] ISGylation of protein phosphatase 1 beta (PP2CB) [Reaction:R-MMU-1169402] ISGylation of E2 conjugating enzymes [Reaction:R-MMU-1169398] ISGylation of host protein filamin B [BlackBoxEvent:R-MMU-9833973] ISGylation of PKR [Reaction:R-MMU-1169394] ISGylation of IRF3
(inferredTo)	[Reaction:R-HSA-1169403] Interaction of E3 ligase with ISG15:E2 complex