Interaction of E3 ligase with ISG15:E2 complex

Stable Identifier
Reaction [binding]
Homo sapiens
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Ubiquitin ligase HERC5/CEB1 appears to be the predominant E3 ligase for ISGylation; EFP and HHARI/ARIH1 have also been reported as ISG15 E3 ligases. The E3 ligase recognizes specific target substrates and mediates the transfer of ISG15 from E2 to the substrate.

Literature References
PubMed ID Title Journal Year
17289916 ISG15 modification of the eIF4E cognate 4EHP enhances cap structure-binding activity of 4EHP

Zhang, DE, Okumura, F, Zou, W

Genes Dev 2007
16352599 The interferon-inducible ubiquitin-protein isopeptide ligase (E3) EFP also functions as an ISG15 E3 ligase

Zhang, DE, Zou, W

J Biol Chem 2006
16815975 HERC5 is an IFN-induced HECT-type E3 protein ligase that mediates type I IFN-induced ISGylation of protein targets

Wong, JJ, Chin, KC, Pung, YF, Sze, NS

Proc Natl Acad Sci U S A 2006
16407192 Herc5, an interferon-induced HECT E3 enzyme, is required for conjugation of ISG15 in human cells

Kelley, M, Beaudenon, S, Krug, RM, Dastur, A, Huibregtse, JM

J Biol Chem 2006
Orthologous Events
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