Reactome | Interaction of E3 ligase with ISG15:E2 complex

Interaction of E3 ligase with ISG15:E2 complex

Stable Identifier

R-HSA-1169403

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Interaction of E3 ligase with ISG15:E2 complex

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Ubiquitin ligase HERC5/CEB1 appears to be the predominant E3 ligase for ISGylation; EFP and HHARI/ARIH1 have also been reported as ISG15 E3 ligases. The E3 ligase recognizes specific target substrates and mediates the transfer of ISG15 from E2 to the substrate.

Literature References

PubMed ID	Title	Journal	Year
17289916	ISG15 modification of the eIF4E cognate 4EHP enhances cap structure-binding activity of 4EHP Zhang, DE, Okumura, F, Zou, W	Genes Dev	2007
16352599	The interferon-inducible ubiquitin-protein isopeptide ligase (E3) EFP also functions as an ISG15 E3 ligase Zhang, DE, Zou, W	J Biol Chem	2006
16815975	HERC5 is an IFN-induced HECT-type E3 protein ligase that mediates type I IFN-induced ISGylation of protein targets Wong, JJ, Chin, KC, Pung, YF, Sze, NS	Proc Natl Acad Sci U S A	2006
16407192	Herc5, an interferon-induced HECT E3 enzyme, is required for conjugation of ISG15 in human cells Kelley, M, Beaudenon, S, Krug, RM, Dastur, A, Huibregtse, JM	J Biol Chem	2006