Reactome | Cleavage of Procaspase-3 by the apoptosome

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Cleavage of Procaspase-3 by the apoptosome Show undefined attributes

authored	[InstanceEdit:111451] Alnemri, E, 2004-02-17 00:23:30
catalystActivity	[CatalystActivity:204205] cysteine-type endopeptidase activity of Apoptosome [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:111451] Alnemri, E, 2004-02-17 00:23:30
dbId	114252
displayName	Cleavage of Procaspase-3 by the apoptosome
eventOf	[Pathway:R-HSA-111459] Activation of caspases through apoptosome-mediated cleavage - Homo sapiens
followingEvent	[Reaction:R-HSA-9627104] XIAP binds CASP3 - Homo sapiens [Reaction:R-HSA-211219] Translocation of caspase-3 to the nucleus - Homo sapiens [Reaction:R-HSA-202947] Caspase mediated cleavage of APC - Homo sapiens [Reaction:R-HSA-201603] Caspase-mediated cleavage of PKC theta - Homo sapiens [Reaction:R-HSA-202967] Caspase mediated cleavage of alpha-II-Fodrin - Homo sapiens [Reaction:R-HSA-201639] Caspase-mediated cleavage of GAS2 - Homo sapiens [Reaction:R-HSA-202966] Caspase mediated cleavage of HIP-55 - Homo sapiens [Reaction:R-HSA-201622] Caspase-mediated cleavage of gelsolin - Homo sapiens [Reaction:R-HSA-201608] Caspase-mediated cleavage of alpha adducin - Homo sapiens [Reaction:R-HSA-201629] Caspase-mediated cleavage of Tau - Homo sapiens [Reaction:R-HSA-201628] Caspase-mediated cleavage of vimentin at DSVD (85) - Homo sapiens [Reaction:R-HSA-351877] Caspase-mediated cleavage of Desmoglein 2 - Homo sapiens [Reaction:R-HSA-202917] Caspase-mediated cleavage of Desmoglein 1 - Homo sapiens [Reaction:R-HSA-202939] Caspase-mediated cleavage of E-Cadherin - Homo sapiens [Reaction:R-HSA-202969] Caspase mediated cleavage of beta-catenin - Homo sapiens [Reaction:R-HSA-201631] Caspase-mediated cleavage of Desmoglein 3 - Homo sapiens [Reaction:R-HSA-201611] Caspase-mediated cleavage of Rock-1 - Homo sapiens [Reaction:R-HSA-212552] Caspase 3-mediated cleavage of PKC delta - Homo sapiens [Reaction:R-HSA-201640] Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha - Homo sapiens [Reaction:R-HSA-351849] Caspase-mediated cleavage of Etk - Homo sapiens [Reaction:R-HSA-202960] Caspase mediated cleavage of C-IAP1 - Homo sapiens [Reaction:R-HSA-201630] Caspase-mediated cleavage of Acinus - Homo sapiens [Reaction:R-HSA-350651] Caspase-mediated cleavage of MASK - Homo sapiens [Reaction:R-HSA-211651] Cleavage of PAK-2 at 212 - Homo sapiens [BlackBoxEvent:R-HSA-9647632] CASP3 cleaves GSDME - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-6804299] CASP3(1-277) dimer [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:141214] Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. [LiteratureReference:141215] An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9. [LiteratureReference:6804302] Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	Cleavage of Procaspase-3 by the apoptosome
orthologousEvent	[Reaction:R-MMU-114252] Cleavage of Procaspase-3 by the apoptosome - Mus musculus [Reaction:R-RNO-114252] Cleavage of Procaspase-3 by the apoptosome - Rattus norvegicus [Reaction:R-CFA-114252] Cleavage of Procaspase-3 by the apoptosome - Canis familiaris [Reaction:R-BTA-114252] Cleavage of Procaspase-3 by the apoptosome - Bos taurus [Reaction:R-SSC-114252] Cleavage of Procaspase-3 by the apoptosome - Sus scrofa [Reaction:R-DRE-114252] Cleavage of Procaspase-3 by the apoptosome - Danio rerio [Reaction:R-XTR-114252] Cleavage of Procaspase-3 by the apoptosome - Xenopus tropicalis [Reaction:R-GGA-114252] Cleavage of Procaspase-3 by the apoptosome - Gallus gallus [Reaction:R-DME-114252] Cleavage of Procaspase-3 by the apoptosome - Drosophila melanogaster
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-350870] Caspase-3 [cytosol]
precedingEvent	[Reaction:R-HSA-114259] Cleavage of Procaspase?9 to caspase?9 - Homo sapiens
regulatedBy	[NegativeRegulation:9627060] Negative regulation by 'XIAP [cytosol]'
regulationReference	[RegulationReference:9641669] Negative regulation by 'XIAP [cytosol]' Regulation of the Apaf-1-caspase-9 apoptosome
releaseDate	2004-10-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9620504] Matthews, Lisa, 2018-09-25
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-114252
summation	[Summation:212499] Caspases-3 and -7 are directly cleaved downstream of caspase...
updateTrackers	[UpdateTracker:9783866] Update Tracker - [Reaction:114252] Cleavage of Procaspase-3 by the apoptosome - v55:[addLiteratureReference, add_removeInput, add_removeOutput] [UpdateTracker:9791800] Update Tracker - [Reaction:114252] Cleavage of Procaspase-3 by the apoptosome - v25:[addInput, addOutput] [UpdateTracker:9778791] Update Tracker - [Reaction:114252] Cleavage of Procaspase-3 by the apoptosome - v67:[addRegulator] [UpdateTracker:9792133] Update Tracker - [Reaction:114252] Cleavage of Procaspase-3 by the apoptosome - v23:[add_removeCatalystActivity] [UpdateTracker:9792073] Update Tracker - [Reaction:114252] Cleavage of Procaspase-3 by the apoptosome - v24:[add_removeSummation]

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-9647632] CASP3 cleaves GSDME [Reaction:R-HSA-9627104] XIAP binds CASP3 [Reaction:R-HSA-211651] Cleavage of PAK-2 at 212 [Reaction:R-HSA-211219] Translocation of caspase-3 to the nucleus [Reaction:R-HSA-202947] Caspase mediated cleavage of APC [Reaction:R-HSA-201603] Caspase-mediated cleavage of PKC theta [Reaction:R-HSA-202967] Caspase mediated cleavage of alpha-II-Fodrin [Reaction:R-HSA-201639] Caspase-mediated cleavage of GAS2 [Reaction:R-HSA-202966] Caspase mediated cleavage of HIP-55 [Reaction:R-HSA-201622] Caspase-mediated cleavage of gelsolin [Reaction:R-HSA-201608] Caspase-mediated cleavage of alpha adducin [Reaction:R-HSA-201629] Caspase-mediated cleavage of Tau [Reaction:R-HSA-201628] Caspase-mediated cleavage of vimentin at DSVD (85) [Reaction:R-HSA-351877] Caspase-mediated cleavage of Desmoglein 2 [Reaction:R-HSA-202917] Caspase-mediated cleavage of Desmoglein 1 [Reaction:R-HSA-202939] Caspase-mediated cleavage of E-Cadherin [Reaction:R-HSA-202969] Caspase mediated cleavage of beta-catenin [Reaction:R-HSA-201631] Caspase-mediated cleavage of Desmoglein 3 [Reaction:R-HSA-201611] Caspase-mediated cleavage of Rock-1 [Reaction:R-HSA-212552] Caspase 3-mediated cleavage of PKC delta [Reaction:R-HSA-201640] Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha [Reaction:R-HSA-351849] Caspase-mediated cleavage of Etk [Reaction:R-HSA-202960] Caspase mediated cleavage of C-IAP1 [Reaction:R-HSA-201630] Caspase-mediated cleavage of Acinus [Reaction:R-HSA-350651] Caspase-mediated cleavage of MASK
(hasEvent)	[Pathway:R-HSA-111459] Activation of caspases through apoptosome-mediated cleavage
(updatedInstance)	[UpdateTracker:9783866] Update Tracker - [Reaction:114252] Cleavage of Procaspase-3 by the apoptosome - v55:[addLiteratureReference, add_removeInput, add_removeOutput] [UpdateTracker:9791800] Update Tracker - [Reaction:114252] Cleavage of Procaspase-3 by the apoptosome - v25:[addInput, addOutput] [UpdateTracker:9778791] Update Tracker - [Reaction:114252] Cleavage of Procaspase-3 by the apoptosome - v67:[addRegulator] [UpdateTracker:9792133] Update Tracker - [Reaction:114252] Cleavage of Procaspase-3 by the apoptosome - v23:[add_removeCatalystActivity] [UpdateTracker:9792073] Update Tracker - [Reaction:114252] Cleavage of Procaspase-3 by the apoptosome - v24:[add_removeSummation]

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