Reactome | Cleavage of Procaspase-3 by the apoptosome

Cleavage of Procaspase-3 by the apoptosome

Stable Identifier

R-HSA-114252

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

Programmed Cell Death (Homo sapiens)

- Apoptosis (Homo sapiens)
  - Intrinsic Pathway for Apoptosis (Homo sapiens)
    - Apoptotic factor-mediated response (Homo sapiens)
      - Cytochrome c-mediated apoptotic response (Homo sapiens)
        
        Activation of caspases through apoptosome-mediated cleavage (Homo sapiens)
        
        Cleavage of Procaspase-3 by the apoptosome (Homo sapiens)

General

SBML | | PDF

SVG | | PPTX | SBGN

Cleavage of Procaspase-3 by the apoptosome

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Caspases-3 and -7 are directly cleaved downstream of caspase-9 in the cytochrome c/Apaf-1-inducible caspase cascade (Slee et al., 1999).

Literature References

PubMed ID	Title	Journal	Year
23650375	Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation Thomsen, ND, Koerber, JT, Wells, JA	Proc. Natl. Acad. Sci. U.S.A.	2013
9390557	Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Srinivasula, SM, Wang, X, Budihardjo, I, Nijhawan, D, Li, P, Alnemri, ES	Cell	1997
10206961	An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9. Liu, X, Li, Y, Wang, X, Zou, H	J Biol Chem	1999