Cleavage of Procaspase-3 by the apoptosome

Stable Identifier
R-HSA-114252
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Cleavage of Procaspase-3 by the apoptosome
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Caspases-3 and -7 are directly cleaved downstream of caspase-9 in the cytochrome c/Apaf-1-inducible caspase cascade (Slee et al., 1999).

Literature References
PubMed ID Title Journal Year
9390557 Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade.

Li, P, Nijhawan, D, Budihardjo, I, Srinivasula, SM, Alnemri, ES, Wang, X

Cell 1997
10206961 An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9.

Zou, H, Li, Y, Liu, X, Wang, X

J Biol Chem 1999
23650375 Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation

Thomsen, ND, Koerber, JT, Wells, JA

Proc. Natl. Acad. Sci. U.S.A. 2013
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
cysteine-type endopeptidase activity of Apoptosome [cytosol]
Physical Entity
Apoptosome [cytosol]
Activity
cysteine-type endopeptidase activity (0004197)
This event is regulated
Negatively by
Orthologous Events
Cleavage of Procaspase-3 by the apoptosome (Danio rerio)
Cleavage of Procaspase-3 by the apoptosome (Drosophila melanogaster)
Cleavage of Procaspase-3 by the apoptosome (Gallus gallus)
Cleavage of Procaspase-3 by the apoptosome (Mus musculus)
Cleavage of Procaspase-3 by the apoptosome (Rattus norvegicus)
Authored
Alnemri, E  (2004-02-17)
Reviewed
Matthews, L  (2018-09-25)
Created
Alnemri, E  (2004-02-17)
Cite Us!