Cleavage of Procaspase-3 by the apoptosome

Stable Identifier
R-HSA-114252
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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Cleavage of Procaspase-3 by the apoptosome
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Caspases-3 and -7 are directly cleaved downstream of caspase-9 in the cytochrome c/Apaf-1-inducible caspase cascade (Slee et al., 1999).

Literature References
PubMed ID Title Journal Year
9390557 Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade.

Li, P, Nijhawan, D, Budihardjo, I, Srinivasula, SM, Alnemri, ES, Wang, X

Cell 1997
10206961 An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9.

Zou, H, Li, Y, Liu, X, Wang, X

J Biol Chem 1999
23650375 Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation

Thomsen, ND, Koerber, JT, Wells, JA

Proc. Natl. Acad. Sci. U.S.A. 2013
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
cysteine-type endopeptidase activity of Apoptosome [cytosol]
Physical Entity
Apoptosome [cytosol]
Activity
cysteine-type endopeptidase activity (0004197)
This event is regulated
Negatively by
Authored
Alnemri, E  (2004-02-17)
Reviewed
Matthews, L  (2018-09-25)
Created
Alnemri, E  (2004-02-17)