Cleavage of Procaspase-3 by the apoptosome

Stable Identifier
R-HSA-114252
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Caspases-3 and -7 are directly cleaved downstream of caspase-9 in the cytochrome c/Apaf-1-inducible caspase cascade (Slee et al., 1999).
Literature References
PubMed ID Title Journal Year
23650375 Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation

Thomsen, ND, Koerber, JT, Wells, JA

Proc. Natl. Acad. Sci. U.S.A. 2013
9390557 Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade.

Srinivasula, SM, Wang, X, Budihardjo, I, Nijhawan, D, Li, P, Alnemri, ES

Cell 1997
10206961 An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9.

Liu, X, Li, Y, Wang, X, Zou, H

J Biol Chem 1999
Participants
Participates
Catalyst Activity

cysteine-type endopeptidase activity of Apoptosome [cytosol]

This event is regulated
Negatively by
Orthologous Events
Authored
Reviewed
Created
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