Reactome | Cleavage of Procaspase-3 by the apoptosome

Cleavage of Procaspase-3 by the apoptosome

Stable Identifier

R-HSA-114252

Type

Reaction

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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Programmed Cell Death (Homo sapiens)

- Apoptosis (Homo sapiens)
  - Intrinsic Pathway for Apoptosis (Homo sapiens)
    - Apoptotic factor-mediated response (Homo sapiens)
      - Cytochrome c-mediated apoptotic response (Homo sapiens)
        
        Activation of caspases through apoptosome-mediated cleavage (Homo sapiens)
        
        Cleavage of Procaspase-3 by the apoptosome (Homo sapiens)

General

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Cleavage of Procaspase-3 by the apoptosome

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Caspases-3 and -7 are directly cleaved downstream of caspase-9 in the cytochrome c/Apaf-1-inducible caspase cascade (Slee et al., 1999).

Literature References

PubMed ID	Title	Journal	Year
10206961	An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9. Liu, X, Li, Y, Wang, X, Zou, H	J Biol Chem	1999
9390557	Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Srinivasula, SM, Wang, X, Budihardjo, I, Nijhawan, D, Li, P, Alnemri, ES	Cell	1997
23650375	Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation Thomsen, ND, Koerber, JT, Wells, JA	Proc. Natl. Acad. Sci. U.S.A.	2013