Reactome | Caspase-mediated cleavage of Rock-1

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Caspase-mediated cleavage of Rock-1 Show undefined attributes

authored	[InstanceEdit:201620] Schulze-Osthoff, K, 2007-09-03 07:52:18
catalystActivity	[CatalystActivity:114327] cysteine-type endopeptidase activity of Caspase-3 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:201610] Matthews, L, 2007-09-03 08:36:41
dbId	201611
displayName	Caspase-mediated cleavage of Rock-1
edited	[InstanceEdit:201589] Matthews, L, 2007-09-03 07:38:20 [InstanceEdit:211656] Matthews, L, 2008-02-08 00:35:06
eventOf	[Pathway:R-HSA-111465] Apoptotic cleavage of cellular proteins - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-212509] ROCK1 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:213418] Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	Caspase-mediated cleavage of Rock-1
orthologousEvent	[Reaction:R-DME-201611] Caspase-mediated cleavage of Rock-1 - Drosophila melanogaster [Reaction:R-GGA-201611] Caspase-mediated cleavage of Rock-1 - Gallus gallus [Reaction:R-XTR-201611] Caspase-mediated cleavage of Rock-1 - Xenopus tropicalis [Reaction:R-SSC-201611] Caspase-mediated cleavage of Rock-1 - Sus scrofa [Reaction:R-BTA-201611] Caspase-mediated cleavage of Rock-1 - Bos taurus [Reaction:R-CFA-201611] Caspase-mediated cleavage of Rock-1 - Canis familiaris [Reaction:R-RNO-201611] Caspase-mediated cleavage of Rock-1 - Rattus norvegicus [Reaction:R-MMU-201611] Caspase-mediated cleavage of Rock-1 - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-212523] ROCK1(1-1113) [cytosol] [EntityWithAccessionedSequence:R-HSA-212524] ROCK1(1114-1354) [cytosol]
precedingEvent	[Reaction:R-HSA-114252] Cleavage of Procaspase-3 by the apoptosome - Homo sapiens [Reaction:R-HSA-114419] Dissociation of Caspase-3 from DIABLO:XIAP:Caspase-3 - Homo sapiens [Reaction:R-HSA-418845] Activation of caspase-3 - Homo sapiens
releaseDate	2006-08-02
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:204051] Ranganathan, S, 2007-11-23 00:10:26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-201611
summation	[Summation:212559] Caspase-3-mediated cleavage of ROCK I induces MLC phosphoryl...

Referrals

(hasEvent)

[Pathway:R-HSA-111465] Apoptotic cleavage of cellular proteins