Reactome | Caspase-mediated cleavage of Desmoglein 1

Schema > Reaction > Entries

Caspase-mediated cleavage of Desmoglein 1 Show undefined attributes

authored	[InstanceEdit:201620] Schulze-Osthoff, K, 2007-09-03 07:52:18
catalystActivity	[CatalystActivity:114327] cysteine-type endopeptidase activity of Caspase-3 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:202923] Matthews, L, 2007-11-12 10:03:15
dbId	202917
displayName	Caspase-mediated cleavage of Desmoglein 1
edited	[InstanceEdit:201589] Matthews, L, 2007-09-03 07:38:20 [InstanceEdit:201989] Matthews, L, 2007-10-09 13:44:38 [InstanceEdit:202801] Matthews, L, 2007-11-11 23:40:56 [InstanceEdit:351949] Matthews, L, 2008-05-28 22:59:08
eventOf	[Pathway:R-HSA-351906] Apoptotic cleavage of cell adhesion proteins - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-202912] DSG1 [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:202907] The differentiation-dependent desmosomal cadherin desmoglein 1 is a novel caspase-3 target that regulates apoptosis in keratinocytes
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	Caspase-mediated cleavage of Desmoglein 1
orthologousEvent	[Reaction:R-DME-202917] Caspase-mediated cleavage of Desmoglein 1 - Drosophila melanogaster [Reaction:R-GGA-202917] Caspase-mediated cleavage of Desmoglein 1 - Gallus gallus [Reaction:R-XTR-202917] Caspase-mediated cleavage of Desmoglein 1 - Xenopus tropicalis [Reaction:R-DRE-202917] Caspase-mediated cleavage of Desmoglein 1 - Danio rerio [Reaction:R-SSC-202917] Caspase-mediated cleavage of Desmoglein 1 - Sus scrofa [Reaction:R-BTA-202917] Caspase-mediated cleavage of Desmoglein 1 - Bos taurus [Reaction:R-CFA-202917] Caspase-mediated cleavage of Desmoglein 1 - Canis familiaris [Reaction:R-RNO-202917] Caspase-mediated cleavage of Desmoglein 1 - Rattus norvegicus [Reaction:R-MMU-202917] Caspase-mediated cleavage of Desmoglein 1 - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-202922] DSG1(50-888) [plasma membrane] [EntityWithAccessionedSequence:R-HSA-202921] DSG1(889-1049) [cytosol]
precedingEvent	[Reaction:R-HSA-114252] Cleavage of Procaspase-3 by the apoptosome - Homo sapiens [Reaction:R-HSA-114419] Dissociation of Caspase-3 from DIABLO:XIAP:Caspase-3 - Homo sapiens [Reaction:R-HSA-418845] Activation of caspase-3 - Homo sapiens
releaseDate	2008-06-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:350641] Ranganathan, S, 2008-06-11 19:13:33
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-202917
summation	[Summation:202911] Caspase mediated cleavage of desmoglein 1 leads to decreased...
updateTrackers	[UpdateTracker:9779859] Update Tracker - [Reaction:202917] Caspase-mediated cleavage of Desmoglein 1 - v64:[add_removeCatalystActivity]

Referrals

(updatedInstance)	[UpdateTracker:9779859] Update Tracker - [Reaction:202917] Caspase-mediated cleavage of Desmoglein 1 - v64:[add_removeCatalystActivity]
(hasEvent)	[Pathway:R-HSA-351906] Apoptotic cleavage of cell adhesion proteins