Reactome | Caspase-mediated cleavage of GAS2

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Caspase-mediated cleavage of GAS2 Show undefined attributes

authored	[InstanceEdit:201620] Schulze-Osthoff, K, 2007-09-03 07:52:18
catalystActivity	[CatalystActivity:202853] cysteine-type endopeptidase activity of Caspase-3, Caspase-7 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:201633] Matthews, L, 2007-09-03 08:38:43
dbId	201639
displayName	Caspase-mediated cleavage of GAS2
edited	[InstanceEdit:201589] Matthews, L, 2007-09-03 07:38:20 [InstanceEdit:201989] Matthews, L, 2007-10-09 13:44:38 [InstanceEdit:202801] Matthews, L, 2007-11-11 23:40:56
eventOf	[Pathway:R-HSA-264870] Caspase-mediated cleavage of cytoskeletal proteins - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-201614] GAS2 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:202842] Microfilament reorganization during apoptosis: the role of Gas2, a possible substrate for ICE-like proteases [LiteratureReference:202885] Caspase-3 and caspase-7 but not caspase-6 cleave Gas2 in vitro: implications for microfilament reorganization during apoptosis
maxDepth	1
modified	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
name	Caspase-mediated cleavage of GAS2
orthologousEvent	[Reaction:R-XTR-201639] Caspase-mediated cleavage of GAS2 - Xenopus tropicalis [Reaction:R-DRE-201639] Caspase-mediated cleavage of GAS2 - Danio rerio [Reaction:R-SSC-201639] Caspase-mediated cleavage of GAS2 - Sus scrofa [Reaction:R-BTA-201639] Caspase-mediated cleavage of GAS2 - Bos taurus [Reaction:R-CFA-201639] Caspase-mediated cleavage of GAS2 - Canis familiaris [Reaction:R-RNO-201639] Caspase-mediated cleavage of GAS2 - Rattus norvegicus [Reaction:R-MMU-201639] Caspase-mediated cleavage of GAS2 - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-202833] GAS2(1-279) [cytosol] [EntityWithAccessionedSequence:R-HSA-202887] GAS2(280-313) [cytosol]
precedingEvent	[Reaction:R-HSA-114252] Cleavage of Procaspase-3 by the apoptosome - Homo sapiens [Reaction:R-HSA-114261] Cleavage of Procaspase-7 by the apoptosome - Homo sapiens [Reaction:R-HSA-114419] Dissociation of Caspase-3 from DIABLO:XIAP:Caspase-3 - Homo sapiens [Reaction:R-HSA-114392] Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 - Homo sapiens [Reaction:R-HSA-418845] Activation of caspase-3 - Homo sapiens
releaseDate	2005-09-26
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:204051] Ranganathan, S, 2007-11-23 00:10:26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-201639
summation	[Summation:202884] Cleavage of Gas2 during apoptosis is associated with changes...
updateTrackers	[UpdateTracker:9782175] Update Tracker - [Reaction:201639] Caspase-mediated cleavage of GAS2 - v59:[add_removeLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9782175] Update Tracker - [Reaction:201639] Caspase-mediated cleavage of GAS2 - v59:[add_removeLiteratureReference]
(hasEvent)	[Pathway:R-HSA-264870] Caspase-mediated cleavage of cytoskeletal proteins

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