Reactome | Cleavage of Procaspase-3 by the apoptosome

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Cleavage of Procaspase-3 by the apoptosome Show undefined attributes

catalystActivity	[CatalystActivity:10341274] cysteine-type endopeptidase activity of Apoptosome [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10341276
displayName	Cleavage of Procaspase-3 by the apoptosome
eventOf	[Pathway:R-BTA-111459] Activation of caspases through apoptosome-mediated cleavage - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-9627104] XIAP binds CASP3 - Bos taurus [Reaction:R-BTA-350651] Caspase-mediated cleavage of MASK - Bos taurus [Reaction:R-BTA-201630] Caspase-mediated cleavage of Acinus - Bos taurus [Reaction:R-BTA-202960] Caspase mediated cleavage of C-IAP1 - Bos taurus [Reaction:R-BTA-351849] Caspase-mediated cleavage of Etk - Bos taurus [Reaction:R-BTA-201640] Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha - Bos taurus [Reaction:R-BTA-212552] Caspase 3-mediated cleavage of PKC delta - Bos taurus [Reaction:R-BTA-201611] Caspase-mediated cleavage of Rock-1 - Bos taurus [Reaction:R-BTA-201631] Caspase-mediated cleavage of Desmoglein 3 - Bos taurus [Reaction:R-BTA-202969] Caspase mediated cleavage of beta-catenin - Bos taurus [Reaction:R-BTA-202939] Caspase-mediated cleavage of E-Cadherin - Bos taurus [Reaction:R-BTA-202917] Caspase-mediated cleavage of Desmoglein 1 - Bos taurus [Reaction:R-BTA-351877] Caspase-mediated cleavage of Desmoglein 2 - Bos taurus [Reaction:R-BTA-201628] Caspase-mediated cleavage of vimentin at DSVD (85) - Bos taurus [Reaction:R-BTA-201608] Caspase-mediated cleavage of alpha adducin - Bos taurus [Reaction:R-BTA-201622] Caspase-mediated cleavage of gelsolin - Bos taurus [Reaction:R-BTA-202966] Caspase mediated cleavage of HIP-55 - Bos taurus [Reaction:R-BTA-201639] Caspase-mediated cleavage of GAS2 - Bos taurus [Reaction:R-BTA-202967] Caspase mediated cleavage of alpha-II-Fodrin - Bos taurus [Reaction:R-BTA-201603] Caspase-mediated cleavage of PKC theta - Bos taurus [Reaction:R-BTA-202947] Caspase mediated cleavage of APC - Bos taurus [Reaction:R-BTA-211219] Translocation of caspase-3 to the nucleus - Bos taurus [BlackBoxEvent:R-BTA-9647632] CASP3 cleaves GSDME - Bos taurus
inferredFrom	[Reaction:R-HSA-114252] Cleavage of Procaspase-3 by the apoptosome - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-BTA-6804299] CASP3(1-277) dimer [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Cleavage of Procaspase-3 by the apoptosome
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-BTA-350870] Caspase-3 [cytosol]
precedingEvent	[Reaction:R-BTA-114259] Cleavage of Procaspase?9 to caspase?9 - Bos taurus
regulatedBy	[NegativeRegulation:10341277] Negative regulation by 'XIAP [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-114252
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[BlackBoxEvent:R-BTA-9647632] CASP3 cleaves GSDME [Reaction:R-BTA-9627104] XIAP binds CASP3 [Reaction:R-BTA-350651] Caspase-mediated cleavage of MASK [Reaction:R-BTA-201630] Caspase-mediated cleavage of Acinus [Reaction:R-BTA-202960] Caspase mediated cleavage of C-IAP1 [Reaction:R-BTA-351849] Caspase-mediated cleavage of Etk [Reaction:R-BTA-201640] Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha [Reaction:R-BTA-212552] Caspase 3-mediated cleavage of PKC delta [Reaction:R-BTA-201611] Caspase-mediated cleavage of Rock-1 [Reaction:R-BTA-201631] Caspase-mediated cleavage of Desmoglein 3 [Reaction:R-BTA-202969] Caspase mediated cleavage of beta-catenin [Reaction:R-BTA-202939] Caspase-mediated cleavage of E-Cadherin [Reaction:R-BTA-202917] Caspase-mediated cleavage of Desmoglein 1 [Reaction:R-BTA-351877] Caspase-mediated cleavage of Desmoglein 2 [Reaction:R-BTA-201628] Caspase-mediated cleavage of vimentin at DSVD (85) [Reaction:R-BTA-201608] Caspase-mediated cleavage of alpha adducin [Reaction:R-BTA-201622] Caspase-mediated cleavage of gelsolin [Reaction:R-BTA-202966] Caspase mediated cleavage of HIP-55 [Reaction:R-BTA-201639] Caspase-mediated cleavage of GAS2 [Reaction:R-BTA-202967] Caspase mediated cleavage of alpha-II-Fodrin [Reaction:R-BTA-201603] Caspase-mediated cleavage of PKC theta [Reaction:R-BTA-202947] Caspase mediated cleavage of APC [Reaction:R-BTA-211219] Translocation of caspase-3 to the nucleus
(hasEvent)	[Pathway:R-BTA-111459] Activation of caspases through apoptosome-mediated cleavage
(inferredTo)	[Reaction:R-HSA-114252] Cleavage of Procaspase-3 by the apoptosome

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