Reactome | Caspase mediated cleavage of APC

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Caspase mediated cleavage of APC Show undefined attributes

authored	[InstanceEdit:201620] Schulze-Osthoff, K, 2007-09-03 07:52:18
catalystActivity	[CatalystActivity:114327] cysteine-type endopeptidase activity of Caspase-3 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:202941] Matthews, L, 2007-11-12 10:29:00
dbId	202947
displayName	Caspase mediated cleavage of APC
edited	[InstanceEdit:201989] Matthews, L, 2007-10-09 13:44:38 [InstanceEdit:202801] Matthews, L, 2007-11-11 23:40:56
eventOf	[Pathway:R-HSA-111465] Apoptotic cleavage of cellular proteins - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-2976015] APC [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:202903] Caspase-mediated cleavage of APC results in an amino-terminal fragment with an intact armadillo repeat domain [LiteratureReference:202841] The adenomatous polyposis coli protein and retinoblastoma protein are cleaved early in apoptosis and are potential substrates for caspases [LiteratureReference:202835] Caspase cleavage of the APC tumor suppressor and release of an amino-terminal domain is required for the transcription-independent function of APC in apoptosis
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	Caspase mediated cleavage of APC
orthologousEvent	[Reaction:R-DME-202947] Caspase mediated cleavage of APC - Drosophila melanogaster [Reaction:R-GGA-202947] Caspase mediated cleavage of APC - Gallus gallus [Reaction:R-XTR-202947] Caspase mediated cleavage of APC - Xenopus tropicalis [Reaction:R-DRE-202947] Caspase mediated cleavage of APC - Danio rerio [Reaction:R-SSC-202947] Caspase mediated cleavage of APC - Sus scrofa [Reaction:R-BTA-202947] Caspase mediated cleavage of APC - Bos taurus [Reaction:R-CFA-202947] Caspase mediated cleavage of APC - Canis familiaris [Reaction:R-RNO-202947] Caspase mediated cleavage of APC - Rattus norvegicus [Reaction:R-MMU-202947] Caspase mediated cleavage of APC - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-2976014] APC(1-777) [cytosol] [EntityWithAccessionedSequence:R-HSA-2976013] APC(778-2843) [cytosol]
precedingEvent	[Reaction:R-HSA-114252] Cleavage of Procaspase-3 by the apoptosome - Homo sapiens [Reaction:R-HSA-114419] Dissociation of Caspase-3 from DIABLO:XIAP:Caspase-3 - Homo sapiens [Reaction:R-HSA-418845] Activation of caspase-3 - Homo sapiens
releaseDate	2007-12-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:204051] Ranganathan, S, 2007-11-23 00:10:26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-202947
summation	[Summation:202860] Cleavage of APC by caspase 3 and release of the amino-term...
updateTrackers	[UpdateTracker:9787674] Update Tracker - [Reaction:202947] Caspase mediated cleavage of APC - v44:[add_removeInput, add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9787674] Update Tracker - [Reaction:202947] Caspase mediated cleavage of APC - v44:[add_removeInput, add_removeOutput]
(hasEvent)	[Pathway:R-HSA-111465] Apoptotic cleavage of cellular proteins

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