Reactome | Apoptotic cleavage of cellular proteins

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Apoptotic cleavage of cellular proteins Show undefined attributes

authored	[InstanceEdit:201620] Schulze-Osthoff, K, 2007-09-03 07:52:18
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:111451] Alnemri, E, 2004-02-17 00:23:30
crossReference	[DatabaseIdentifier:12819573] BioModels Database:BIOMD0000000243 [DatabaseIdentifier:12819457] BioModels Database:BIOMD0000000220 [DatabaseIdentifier:12819459] BioModels Database:BIOMD0000000407
dbId	111465
displayName	Apoptotic cleavage of cellular proteins
edited	[InstanceEdit:211689] Matthews, L, 2008-02-08 00:41:49
eventOf	[Pathway:R-HSA-75153] Apoptotic execution phase - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Pathway:R-HSA-264870] Caspase-mediated cleavage of cytoskeletal proteins - Homo sapiens [Pathway:R-HSA-351906] Apoptotic cleavage of cell adhesion proteins - Homo sapiens [Pathway:R-HSA-352238] Breakdown of the nuclear lamina - Homo sapiens [Reaction:R-HSA-202947] Caspase mediated cleavage of APC - Homo sapiens [Reaction:R-HSA-202960] Caspase mediated cleavage of C-IAP1 - Homo sapiens [Reaction:R-HSA-201634] Caspase-mediated cleavage of FADK 1 - Homo sapiens [Reaction:R-HSA-212552] Caspase 3-mediated cleavage of PKC delta - Homo sapiens [Reaction:R-HSA-201603] Caspase-mediated cleavage of PKC theta - Homo sapiens [Reaction:R-HSA-201630] Caspase-mediated cleavage of Acinus - Homo sapiens [Reaction:R-HSA-201611] Caspase-mediated cleavage of Rock-1 - Homo sapiens [Reaction:R-HSA-201640] Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha - Homo sapiens [Reaction:R-HSA-351894] Caspase mediated cleavage of BAP31 - Homo sapiens [Reaction:R-HSA-351849] Caspase-mediated cleavage of Etk - Homo sapiens [Reaction:R-HSA-350651] Caspase-mediated cleavage of MASK - Homo sapiens [Reaction:R-HSA-351901] Caspase-mediated cleavage of MST3 - Homo sapiens [BlackBoxEvent:R-HSA-9029680] Caspase-7 translocates to the nucleus - Homo sapiens [Reaction:R-HSA-351936] Caspase-mediated cleavage of claspin - Homo sapiens [Reaction:R-HSA-352268] Cleavage of Satb1 - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2018-03-26
literatureReference	[LiteratureReference:201563] Many cuts to ruin: a comprehensive update of caspase substrates [LiteratureReference:204058] SVM-based prediction of caspase substrate cleavage sites [LiteratureReference:204068] CASVM: web server for SVM-based prediction of caspase substrates cleavage sites
maxDepth	3
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	Apoptotic cleavage of cellular proteins
orthologousEvent	[Pathway:R-MMU-111465] Apoptotic cleavage of cellular proteins - Mus musculus [Pathway:R-RNO-111465] Apoptotic cleavage of cellular proteins - Rattus norvegicus [Pathway:R-CFA-111465] Apoptotic cleavage of cellular proteins - Canis familiaris [Pathway:R-BTA-111465] Apoptotic cleavage of cellular proteins - Bos taurus [Pathway:R-SSC-111465] Apoptotic cleavage of cellular proteins - Sus scrofa [Pathway:R-DRE-111465] Apoptotic cleavage of cellular proteins - Danio rerio [Pathway:R-XTR-111465] Apoptotic cleavage of cellular proteins - Xenopus tropicalis [Pathway:R-GGA-111465] Apoptotic cleavage of cellular proteins - Gallus gallus [Pathway:R-DME-111465] Apoptotic cleavage of cellular proteins - Drosophila melanogaster
releaseDate	2007-12-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:204051] Ranganathan, S, 2007-11-23 00:10:26
revised	[InstanceEdit:350336] Matthews, L, 2008-05-18 15:58:28
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-111465
summation	[Summation:204216] Apoptotic cell death is achieved by the caspase-mediated cl...
updateTrackers	[UpdateTracker:9790365] Update Tracker - [Pathway:111465] Apoptotic cleavage of cellular proteins - v33:[addHasEvent] [UpdateTracker:9791660] Update Tracker - [Pathway:111465] Apoptotic cleavage of cellular proteins - v28:[updateIndirectRLE] [UpdateTracker:9789617] Update Tracker - [Pathway:111465] Apoptotic cleavage of cellular proteins - v37:[updateIndirectRLE] [UpdateTracker:9792176] Update Tracker - [Pathway:111465] Apoptotic cleavage of cellular proteins - v23:[addHasEvent, addLiteratureReference, addSummation] [UpdateTracker:9779942] Update Tracker - [Pathway:111465] Apoptotic cleavage of cellular proteins - v64:[addHasEvent, updateContainedPathway, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9791930] Update Tracker - [Pathway:111465] Apoptotic cleavage of cellular proteins - v24:[addHasEvent] [UpdateTracker:9791771] Update Tracker - [Pathway:111465] Apoptotic cleavage of cellular proteins - v26:[addHasEvent] [UpdateTracker:9791887] Update Tracker - [Pathway:111465] Apoptotic cleavage of cellular proteins - v25:[add_removeHasEvent] [UpdateTracker:9790988] Update Tracker - [Pathway:111465] Apoptotic cleavage of cellular proteins - v32:[updateIndirectRLE] [UpdateTracker:9787372] Update Tracker - [Pathway:111465] Apoptotic cleavage of cellular proteins - v45:[updateContainedRLE, updateIndirectRLE] [UpdateTracker:9782266] Update Tracker - [Pathway:111465] Apoptotic cleavage of cellular proteins - v59:[updateIndirectRLE] [UpdateTracker:9787161] Update Tracker - [Pathway:111465] Apoptotic cleavage of cellular proteins - v46:[updateIndirectRLE] [UpdateTracker:9788057] Update Tracker - [Pathway:111465] Apoptotic cleavage of cellular proteins - v44:[updateContainedRLE]

Referrals

(hasEvent)

[Pathway:R-HSA-75153] Apoptotic execution phase

(updatedInstance)

[UpdateTracker:9790365] Update Tracker - [Pathway:111465] Apoptotic cleavage of cellular proteins - v33:[addHasEvent]
[UpdateTracker:9791660] Update Tracker - [Pathway:111465] Apoptotic cleavage of cellular proteins - v28:[updateIndirectRLE]
[UpdateTracker:9789617] Update Tracker - [Pathway:111465] Apoptotic cleavage of cellular proteins - v37:[updateIndirectRLE]
[UpdateTracker:9792176] Update Tracker - [Pathway:111465] Apoptotic cleavage of cellular proteins - v23:[addHasEvent, addLiteratureReference, addSummation]
[UpdateTracker:9779942] Update Tracker - [Pathway:111465] Apoptotic cleavage of cellular proteins - v64:[addHasEvent, updateContainedPathway, updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9791930] Update Tracker - [Pathway:111465] Apoptotic cleavage of cellular proteins - v24:[addHasEvent]
[UpdateTracker:9791771] Update Tracker - [Pathway:111465] Apoptotic cleavage of cellular proteins - v26:[addHasEvent]
[UpdateTracker:9791887] Update Tracker - [Pathway:111465] Apoptotic cleavage of cellular proteins - v25:[add_removeHasEvent]
[UpdateTracker:9790988] Update Tracker - [Pathway:111465] Apoptotic cleavage of cellular proteins - v32:[updateIndirectRLE]
[UpdateTracker:9787372] Update Tracker - [Pathway:111465] Apoptotic cleavage of cellular proteins - v45:[updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9782266] Update Tracker - [Pathway:111465] Apoptotic cleavage of cellular proteins - v59:[updateIndirectRLE]
[UpdateTracker:9787161] Update Tracker - [Pathway:111465] Apoptotic cleavage of cellular proteins - v46:[updateIndirectRLE]
[UpdateTracker:9788057] Update Tracker - [Pathway:111465] Apoptotic cleavage of cellular proteins - v44:[updateContainedRLE]

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