Reactome | Cleavage of Satb1

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Cleavage of Satb1 Show undefined attributes

authored	[InstanceEdit:352235] Schulze-Osthoff, K, 2008-05-18 10:00:05
catalystActivity	[CatalystActivity:352254] cysteine-type endopeptidase activity of active caspase-6 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:352270] Matthews, L, 2008-06-02 08:04:50
dbId	352268
displayName	Cleavage of Satb1
edited	[InstanceEdit:352270] Matthews, L, 2008-06-02 08:04:50 [InstanceEdit:264864] Matthews, L, 2008-04-13 23:06:00
eventOf	[Pathway:R-HSA-111465] Apoptotic cleavage of cellular proteins - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-201593] SATB1 [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:352272] SATB1 cleavage by caspase 6 disrupts PDZ domain-mediated dimerization, causing detachment from chromatin early in T-cell apoptosis
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	Cleavage of Satb1
orthologousEvent	[Reaction:R-DME-352268] Cleavage of Satb1 - Drosophila melanogaster [Reaction:R-GGA-352268] Cleavage of Satb1 - Gallus gallus [Reaction:R-XTR-352268] Cleavage of Satb1 - Xenopus tropicalis [Reaction:R-DRE-352268] Cleavage of Satb1 - Danio rerio [Reaction:R-SSC-352268] Cleavage of Satb1 - Sus scrofa [Reaction:R-BTA-352268] Cleavage of Satb1 - Bos taurus [Reaction:R-CFA-352268] Cleavage of Satb1 - Canis familiaris [Reaction:R-RNO-352268] Cleavage of Satb1 - Rattus norvegicus [Reaction:R-MMU-352268] Cleavage of Satb1 - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-352269] SATB1(1-254) [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-352264] SATB1(255-763) [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-9029690] Caspase-6 translocates to the nucleus - Homo sapiens
releaseDate	2008-06-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:350641] Ranganathan, S, 2008-06-11 19:13:33
revised	[InstanceEdit:350641] Ranganathan, S, 2008-06-11 19:13:33
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-352268
summation	[Summation:352271] Cleaved Satb1 dissociates from chromatin and may function i...

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(hasEvent)

[Pathway:R-HSA-111465] Apoptotic cleavage of cellular proteins