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Apoptotic cleavage of cellular proteins
Stable Identifier
R-HSA-111465
Type
Pathway
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Apoptotic execution phase (Homo sapiens)
Apoptotic cleavage of cellular proteins (Homo sapiens)
General
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Apoptotic cell death is achieved by the caspase-mediated cleavage of various vital proteins. Among caspase targets are proteins such as E-cadherin, Beta-catenin, alpha fodrin, GAS2, FADK, alpha adducin, HIP-55, and desmoglein involved in cell adhesion and maintenance of the cytoskeletal architecture. Cleavage of proteins such as APC and CIAP1 can further stimulate apoptosis by produce proapoptotic proteins (reviewed in Fischer et al., 2003. See also Wee et al., 2006 and the CASVM Caspase Substrates Database: http://www.casbase.org/casvm/squery/index.html ).
Literature References
PubMed ID
Title
Journal
Year
17599937
CASVM: web server for SVM-based prediction of caspase substrates cleavage sites
Tan, TW
,
Ranganathan, S
,
Wee, LJ
Bioinformatics
2007
12655297
Many cuts to ruin: a comprehensive update of caspase substrates
Janicke, RU
,
Schulze-Osthoff, K
,
Fischer, U
Cell Death Differ
2003
17254298
SVM-based prediction of caspase substrate cleavage sites
Tan, TW
,
Ranganathan, S
,
Wee, LJ
BMC Bioinformatics
2006
Participants
Events
Caspase-mediated cleavage of cytoskeletal proteins
(Homo sapiens)
Apoptotic cleavage of cell adhesion proteins
(Homo sapiens)
Breakdown of the nuclear lamina
(Homo sapiens)
Caspase mediated cleavage of APC
(Homo sapiens)
Caspase mediated cleavage of C-IAP1
(Homo sapiens)
Caspase-mediated cleavage of FADK 1
(Homo sapiens)
Caspase 3-mediated cleavage of PKC delta
(Homo sapiens)
Caspase-mediated cleavage of PKC theta
(Homo sapiens)
Caspase-mediated cleavage of Acinus
(Homo sapiens)
Caspase-mediated cleavage of Rock-1
(Homo sapiens)
Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha
(Homo sapiens)
Caspase mediated cleavage of BAP31
(Homo sapiens)
Caspase-mediated cleavage of Etk
(Homo sapiens)
Caspase-mediated cleavage of MASK
(Homo sapiens)
Caspase-mediated cleavage of MST3
(Homo sapiens)
Caspase-7 translocates to the nucleus
(Homo sapiens)
Caspase-mediated cleavage of claspin
(Homo sapiens)
Cleavage of Satb1
(Homo sapiens)
Participates
as an event of
Apoptotic execution phase (Homo sapiens)
Orthologous Events
Apoptotic cleavage of cellular proteins (Bos taurus)
Apoptotic cleavage of cellular proteins (Caenorhabditis elegans)
Apoptotic cleavage of cellular proteins (Canis familiaris)
Apoptotic cleavage of cellular proteins (Danio rerio)
Apoptotic cleavage of cellular proteins (Drosophila melanogaster)
Apoptotic cleavage of cellular proteins (Gallus gallus)
Apoptotic cleavage of cellular proteins (Mus musculus)
Apoptotic cleavage of cellular proteins (Rattus norvegicus)
Apoptotic cleavage of cellular proteins (Sus scrofa)
Apoptotic cleavage of cellular proteins (Xenopus tropicalis)
Cross References
BioModels Database
BIOMD0000000220
,
BIOMD0000000243
,
BIOMD0000000407
Authored
Schulze-Osthoff, K (2007-09-03)
Reviewed
Ranganathan, S (2007-11-23)
Created
Alnemri, E (2004-02-17)
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