Reactome | GORASP1 [Golgi membrane]

GORASP1 [Golgi membrane]

Stable Identifier

R-HSA-6808767

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi membrane

Synonyms

GRASP65, Golgi reassembly-stacking protein 1

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPI-mediated anterograde transport (Homo sapiens)
        
        COPI vesicle uncoating (Homo sapiens)
        
        GOLGA2:GORASP1 [Golgi membrane] (Homo sapiens)
        
        GORASP1 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        GOLGA2:GORASP1 [Golgi membrane] (Homo sapiens)
        
        GORASP1 [Golgi membrane] (Homo sapiens)
        
        Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
        
        GOLGA2:GORASP1 [Golgi membrane] (Homo sapiens)
        
        GORASP1 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        GOLGA2:GORASP1 [Golgi membrane] (Homo sapiens)
        
        GORASP1 [Golgi membrane] (Homo sapiens)
        
        cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        GOLGA2:GORASP1 [Golgi membrane] (Homo sapiens)
        
        GORASP1 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        GOLGA2:GORASP1 [Golgi membrane] (Homo sapiens)
        
        GORASP1 [Golgi membrane] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - ER to Golgi Anterograde Transport (Homo sapiens)
    - COPI-mediated anterograde transport (Homo sapiens)
      - COPI vesicle uncoating (Homo sapiens)
        
        GOLGA2:GORASP1 [Golgi membrane] (Homo sapiens)
        
        GORASP1 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        GOLGA2:GORASP1 [Golgi membrane] (Homo sapiens)
        
        GORASP1 [Golgi membrane] (Homo sapiens)
      - Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
        
        GOLGA2:GORASP1 [Golgi membrane] (Homo sapiens)
        
        GORASP1 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        GOLGA2:GORASP1 [Golgi membrane] (Homo sapiens)
        
        GORASP1 [Golgi membrane] (Homo sapiens)
      - cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        GOLGA2:GORASP1 [Golgi membrane] (Homo sapiens)
        
        GORASP1 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        GOLGA2:GORASP1 [Golgi membrane] (Homo sapiens)
        
        GORASP1 [Golgi membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9BQQ3 GORASP1

Gene Names

GORASP1, GOLPH5, GRASP65

Chain

initiator methionine:, chain:2-440

Reference Genes

BioGPS Gene:64689 GORASP1

COSMIC (genes):GORASP1 GORASP1

CTD Gene:64689 GORASP1

dbSNP Gene:64689 GORASP1

ENSEMBL:ENSG00000114745 GORASP1

HGNC:16769 GORASP1

KEGG:hsa:64689 GORASP1

Monarch:64689 GORASP1

NCBI Gene:64689 GORASP1

OMIM:606867 GORASP1

UCSC:Q9BQQ3 GORASP1

Reference Transcript

Other Identifiers

11748326_a_at

11749903_s_at

11749904_x_at

11758146_s_at

11761222_x_at

16952383

215749_3p_s_at

215749_PM_s_at

215749_s_at

2669889

2669890

2669891

2669892

2669893

2669894

2669895

2669896

2669897

2669898

2669899

2669900

2669901

2669902

2669903

2669904

2669905

2669906

2669907

2669908

2669909

2669910

2669911

2669912

2669913

2669914

2669915

2669916

2669917

2669918

2669920

2669921

2669922

2669923

34812_at

64689

8086317

A_23_P427114

GE55833

GO:0000139

GO:0005515

GO:0005794

GO:0005801

GO:0006486

GO:0006487

GO:0007030

GO:0015031

GO:0016020

GO:0033116

GO:0043226

GO:0046872

GO:0050774

GO:0061951

GO:0072659

GO:0090161

HMNXSV003000013

Hs.4291.1.S1_3p_a_at

Hs.4291.1.S1_3p_s_at

ILMN_1716821

PH_hs_0023232

TC03001301.hg

Participates

as a component of

GOLGA2:GORASP1 [Golgi membrane] (Homo sapiens)

Other forms of this molecule

p-S189,T216,S274,S373-GORASP1 [Golgi membrane]

GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane]

p-T216,S274,S373-GORASP1 [Golgi membrane]

Inferred To

grpA [Golgi membrane] (Dictyostelium discoideum)

GORASP1 [Golgi membrane] (Bos taurus)

GORASP1 [Golgi membrane] (Caenorhabditis elegans)

GORASP1 [Golgi membrane] (Canis familiaris)

GORASP1 [Golgi membrane] (Gallus gallus)

GORASP1 [Golgi membrane] (Mus musculus)

GORASP1 [Golgi membrane] (Rattus norvegicus)

GORASP1 [Golgi membrane] (Schizosaccharomyces pombe)

GORASP1 [Golgi membrane] (Sus scrofa)

Grasp65 [Golgi membrane] (Drosophila melanogaster)

gorasp1 [Golgi membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001265719.1, NP_114105.1, NP_001265718.1

ENSEMBL

ENST00000452389, ENSP00000313869, ENSP00000403552, ENSP00000403167, ENST00000431601, ENST00000319283

OpenTargets

ENSG00000114745

HPA

ENSG00000114745-GORASP1

PRO

Q9BQQ3

Pharos - Targets

Q9BQQ3

PDB

4REY, 6G8T, 6G8W

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O00116 AGPS	4	AGPS(1-58) [peroxisomal matrix] (R-HSA-9033519) AGPS(1-658) [peroxisomal matrix] (R-HSA-9033523) AGPS(1-658) [cytosol] (R-HSA-9033119) AGPS [peroxisomal matrix] (R-HSA-49699)	0.781	7
UniProt:P07196 NEFL	1	NEFL [cytosol] (R-HSA-432284)	0.556	3