CLIP1(1-1083)-LTK(488-864) fusion dimerizes

Stable Identifier
R-HSA-9842659
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
3/5
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CLIP1(1-1083)-LTK(488-864) fusion dimerizes
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A fusion of CLIP1 and LTK has been identified in a small number of non-small cell lung cancer cases (Izumi et al, 2023). The fusion links the coiled-coil dimerization region of CLIP1 with the intracellular kinase domain of LTK. The fusion protein is constitutively active and supports phosphorylation of MAPK and AKT as well as cellular transformation. CLIP1-LTK-positive cells are sensitive to the ALK inhibitor lorlatinib (Izumi et al, 2021).
Literature References
PubMed ID Title Journal Year
34819663 The CLIP1-LTK fusion is an oncogenic driver in non-small-cell lung cancer

Ikeda, T, Nakachi, I, Watanabe, K, Kodani, M, Hayashi, K, Sakakibara-Konishi, J, Shibata, Y, Nishino, K, Izumi, H, Okamoto, I, Kirita, K, Goto, K, Nosaki, K, Yoh, K, Niho, S, Ishii, G, Matsumoto, S, Kuyama, S, Sakai, T, Liu, J, Furuya, N, Sugiyama, E, Nakai, T, Tanaka, K, Kumagai, S, Yamasaki, A, Daga, H, Zenke, Y, Taima, K, Ebi, N, Hayashida, T, Kato, T, Fukuhara, T, Mori, S, Kobayashi, SS, Udagawa, H, Ohtsu, A, Nakamura, A

Nature 2021
Participants
Input
Output
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as an event of
Disease
Name Identifier Synonyms
non-small cell lung carcinoma DOID:3908 Non-small cell lung cancer (disorder), NSCLC, NSCLC
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Rothfels, K  (2023-10-14)
Created
Rothfels, K  (2023-08-27)
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