GHBP binds GHR

Stable Identifier
R-HSA-1362465
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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GHBP, the ectodomain of GHR cleaved from membrane-bound GHR can form a heterodimer with GHR. This is not capable of signaling and may be a negative regulatory influence. GHBP can also inhibit signaling by competing with the full length receptor for GH binding.

Literature References
PubMed ID Title Journal Year
9058373 A short isoform of the human growth hormone receptor functions as a dominant negative inhibitor of the full-length receptor and generates large amounts of binding protein

Ross, RJ, Esposito, N, Shen, XY, Von Laue, S, Chew, SL, Dobson, PR, Postel-Vinay, MC, Finidori, J

Mol Endocrinol 1997
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