GHBP binds GHR

Stable Identifier
R-HSA-1362465
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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GHBP binds GHR
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GHBP, the ectodomain of GHR cleaved from membrane-bound GHR can form a heterodimer with GHR. This is not capable of signaling and may be a negative regulatory influence. GHBP can also inhibit signaling by competing with the full length receptor for GH binding.
Literature References
PubMed ID Title Journal Year
9058373 A short isoform of the human growth hormone receptor functions as a dominant negative inhibitor of the full-length receptor and generates large amounts of binding protein

Ross, RJ, Esposito, N, Shen, XY, Von Laue, S, Chew, SL, Dobson, PR, Postel-Vinay, MC, Finidori, J

Mol Endocrinol 1997
Participants
Input
Output
Participates
as an event of
Orthologous Events
GHBP binds GHR (Danio rerio)
GHBP binds GHR (Gallus gallus)
GHBP binds GHR (Mus musculus)
GHBP binds GHR (Rattus norvegicus)
Authored
Herington, AC  (2011-06-13)
Reviewed
Waters, MJ  (2011-06-23)
Created
Jupe, S  (2011-06-10)
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